Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | GRM4 | Q14833 | 3/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 6/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | IDO1 | P14902 | 1/20 | 0.44 |
| ▸ | TDO2 | P48775 | 1/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | SRC | P12931 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.40 |
| ▸ | P2RY4 | P51582 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3661738 | 0.98 | NPC1 (0.47) | NPC1GRM4HDAC6MAPTKDM4E | |
| Bromide SCHEMBL20984091 | 0.98 | NPC1 (0.47) | NPC1GRM4HDAC6MAPTKDM4E | |
| Oxalic Acid SCHEMBL28374158 | 0.90 | MAPT (0.54) | NPC1GRM4HDAC6MAPTKDM4E | |
| Sulfuric Acid SCHEMBL20984581 | 0.90 | GRM4 (0.48) | NPC1GRM4HDAC6MAPTKDM4E | |
| Phosphoric Acid SCHEMBL28378845 | 0.90 | GRM4 (0.51) | NPC1GRM4HDAC6MAPTKDM4E | |
| Nitric Acid SCHEMBL28377488 | 0.87 | GRM4 (0.46) | NPC1GRM4HDAC6MAPTKDM4E | |
| SCHEMBL5809000 | 0.84 | MAPT (0.54) | NPC1GRM4MAPTPOLBRAB9A | |
| Bromide SCHEMBL20984140 | 0.82 | MAPT (0.53) | NPC1GRM4MAPTPOLBRAB9A | |
| Hydrochloric Acid SCHEMBL4073968 | 0.82 | NPC1 (0.55) | NPC1GRM4MAPTPOLBRAB9A | |
| SCHEMBL8310787 | 0.82 | GRM4 (0.49) | NPC1GRM4HDAC6MAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11759454-B2 | Diazole lactams | CHEMOCENTRYX, INC. (US) | 2023-09-19 | — | — | US | disclosed |
| US-20210093613-A1 | DIAZOLE LACTAMS | CHEMOCENTRYX, INC. | 2021-04-01 | — | — | US | disclosed |
| US-9328116-B2 | Diazole lactams | CHEMOCENTRYX, INC. (US) | 2016-05-03 | — | — | US | disclosed |
| US-20140171420-A1 | DIAZOLE LACTAMS | CHEMOCENTRYX, INC. (US) | 2014-06-19 | — | — | US | disclosed |
| WO-2014089495-A1 | DIAZOLE LACTAMS | CHEMOCENTRYX, INC. (US) | 2014-06-12 | — | — | WO | disclosed |
| US-8076356-B2 | Triazolopyridinylsulfanyl derivatives as P38 map kinase inhibitors | PFIZER INC. (US) | 2011-12-13 | — | — | US | disclosed |
| US-20090239899-A1 | Triazolopyridinylsulfanyl Derivatives As P38 Map Kinase Inhibitors | PFIZER INC. | 2009-09-24 | — | — | US | disclosed |
| EP-1778686-B9 | TRIAZOLOPYRIDINYLSULFANYL DERIVATIVES AS P38 MAP KINASE INHIBITORS | PFIZER LTD (GB) | 2009-07-08 | — | — | EP | disclosed |
| US-7511057-B2 | Triazolopyridinylsulfanyl derivatives as p38 MAP kinase inhibitors | PFIZER INC. (US) | 2009-03-31 | — | — | US | disclosed |
| EP-1778686-B1 | TRIAZOLOPYRIDINYLSULFANYL DERIVATIVES AS P38 MAP KINASE INHIBITORS | PFIZER LTD (GB) | 2008-10-29 | — | — | EP | disclosed |
| US-20060035922-A1 | Triazolopyridinylsulfanyl derivatives as p38 MAP kinase inhibitors | PFIZER INC. | 2006-02-16 | — | — | US | disclosed |
| US-5939558-A | HERBICIDES, DEFOLIANTS | BASF AKTIENGESELLSCHAFT (DE) | 1999-08-17 | — | — | US | disclosed |
| EP-0777654-A1 | N-PHENYLTETRAHYDROINDAZOLES, THEIR PREPARATION, AND THEIR USE AS CROP PROTECTION AGENTS | BASF AKTIENGESELLSCHAFT (DE) | 1997-06-11 | — | — | EP | disclosed |
| WO-1996006830-A1 | N-PHENYLTETRAHYDROINDAZOLES, THEIR PREPARATION, AND THEIR USE AS CROP PROTECTION AGENTS | BASF AKTIENGESELLSCHAFT (DE) | 1996-03-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060035922-A1 | Triazolopyridinylsulfanyl derivatives as p38 MAP kinase inhibitors | MAPK1, MAPKAPK5, MAPKAPK3 | NPC1 1088/4885GRM4 3815/4885HDAC6 311/4885 |
| US-20210093613-A1 | DIAZOLE LACTAMS | CCR1, CCRL2, CCR4 | NPC1 1275/4885GRM4 585/4885HDAC6 1468/4885 |
| US-20140171420-A1 | DIAZOLE LACTAMS | CCR1, CCRL2, CCR4 | NPC1 1275/4885GRM4 585/4885HDAC6 1468/4885 |
| US-11759454-B2 | Diazole lactams | CCR1, CCRL2, CCR4 | NPC1 1275/4885GRM4 585/4885HDAC6 1468/4885 |
| US-20090239899-A1 | Triazolopyridinylsulfanyl Derivatives As P38 Map Kinase Inhibitors | MAPK1, MAPKAPK5, MAPKAPK3 | NPC1 934/4885GRM4 3837/4885HDAC6 264/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.