Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Epoprostenol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGIR known ✓ | P43119 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.82 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | PPARG | P37231 | 1/20 | 0.58 |
| ▸ | PPARD | Q03181 | 1/20 | 0.58 |
| ▸ | PPARA | Q07869 | 1/20 | 0.58 |
| ▸ | PTGFR | P43088 | 5/20 | 0.46 |
| ▸ | PTGER4 | P35408 | 4/20 | 0.46 |
| ▸ | TBXA2R | P21731 | 4/20 | 0.46 |
| ▸ | PTGER2 | P43116 | 3/20 | 0.46 |
| ▸ | TSHR | P16473 | 3/20 | 0.46 |
| ▸ | PTGER1 | P34995 | 2/20 | 0.46 |
| ▸ | PTGER3 | P43115 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.46 |
| ▸ | ESR1 | P03372 | 1/20 | 0.46 |
| ▸ | PGR | P06401 | 1/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Epoprostenol SCHEMBL4299219 | 1.00 | ALDH1A1 (0.82) | ALDH1A1MEN1KMT2APPARGPPARD | |
| Epoprostenol SCHEMBL128619 | 1.00 | ALDH1A1 (0.82) | ALDH1A1MEN1KMT2APPARGPPARD | |
| Epoprostenol SCHEMBL29121502 | 1.00 | ALDH1A1 (0.82) | ALDH1A1MEN1KMT2APPARGPPARD | |
| Epoprostenol SCHEMBL5452422 | 0.96 | ALDH1A1 (0.90) | ALDH1A1MEN1KMT2APPARGPPARD | |
| Epoprostenol SCHEMBL24612535 | 0.90 | ALDH1A1 (1.00) | ALDH1A1MEN1KMT2APPARGPPARD | |
| Epoprostenol SCHEMBL705594 | 0.90 | ALDH1A1 (1.00) | ALDH1A1MEN1KMT2APPARGPPARD | |
| Epoprostenol SCHEMBL16783375 | 0.90 | ALDH1A1 (1.00) | ALDH1A1MEN1KMT2APPARGPPARD | |
| Epoprostenol SCHEMBL24033081 | 0.90 | ALDH1A1 (1.00) | ALDH1A1MEN1KMT2APPARGPPARD | |
| Epoprostenol SCHEMBL21283002 | 0.90 | ALDH1A1 (1.00) | ALDH1A1MEN1KMT2APPARGPPARD | |
| Epoprostenol SCHEMBL22607961 | 0.90 | ALDH1A1 (1.00) | ALDH1A1MEN1KMT2APPARGPPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 2648 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250367179-A1 | COMPOSITION AND METHODS FOR TREATING HERITABLE PULMONARY ARTERY HYPERTENSION ASSOCIATED WITH NONSENSE MUTATIONS | LUNDQUIST INST FOR BIOMEDICAL INNOVATION AT HARBOR UCLA MEDICAL CENTER (US) | 2025-12-04 | — | — | US | claimed |
| US-20250161220-A1 | LYMPHATIC DELIVERY OF NANOPARTICLES TO TREAT NEURODEGENERATIVE, NEUROLOGICAL, AND EYE CONDITIONS | THE CLEVELAND CLINIC FOUNDATION | 2025-05-22 | — | — | US | claimed |
| EP-4479029-A2 | LYMPHATIC DELIVERY OF NANOPARTICLES TO TREAT NEURODEGENERATIVE, NEUROLOGICAL, AND EYE CONDITIONS | The Cleveland Clinic Foundation (US) | 2024-12-25 | — | — | EP | claimed |
| US-20240282425-A1 | AUTHENTICATION METHODS AND SYSTEMS FOR DISPENSED PRESCRIPTIONS | LOW GORDON KEITH (US) | 2024-08-22 | — | — | US | claimed |
| US-20230310478-A1 | METHODS AND COMPOSITIONS FOR THE TREATMENT OF PULMONARY HYPERTENSION AND CANCER | ZHAO, Youyang | 2023-10-05 | — | — | US | claimed |
| WO-2023159114-A2 | LYMPHATIC DELIVERY OF NANOPARTICLES TO TREAT NEURODEGENERATIVE, NEUROLOGICAL, AND EYE CONDITIONS | THE CLEVELAND CLINIC FOUNDATION (US) | 2023-08-24 | — | — | WO | claimed |
| US-11714094-B2 | Composition comprising prostacyclin andor analogues thereof for treatment of acute critically ill patients | ENDOTHEL PHARMA APS (DK) | 2023-08-01 | — | — | US | claimed |
| US-20230000850-A1 | COMPOSITION AND METHODS FOR TREATING HERITABLE PULMONARY ARTERY HYPERTENSION ASSOCIATED WITH NONSENSE MUTATIONS | LUNDQUIST INST FOR BIOMEDICAL INNOVATION AT HARBOR UCLA MEDICAL CENTER (US) | 2023-01-05 | — | — | US | claimed |
| EP-4069826-A1 | EXTRACELLULAR VESICLES AND THEIR USES | United Therapeutics Corporation (US) | 2022-10-12 | — | — | EP | claimed |
| CN-109153660-B | Method for preparing epoprostenol sodium with enhanced stability | 奇诺因药物和化学工厂私人有限公司 | 2022-10-11 | — | — | CN | claimed |
| WO-2002058734-A2 | COMBINATIONS OF STEROL ABSORPTION INHIBITOR(S) WITH BLOOD MODIFIER(S) FOR TREATING VASCULAR CONDITIONS | SCHERING CORPORATION (US) | 2002-08-01 | — | — | WO | claimed |
| US-20020049155-A1 | Cobalamin compounds useful as cardiovascular agents and as imaging agents | HOGENKAMP HENRICUS P C (US) | 2002-04-25 | — | — | US | claimed |
| WO-2002026318-A1 | METHOD AND SYSTEM FOR NERVE STIMULATION AND CARDIAC SENSING PRIOR TO AND DURING A MEDICAL PROCEDURE | MEDTRONIC, INC. (US) | 2002-04-04 | — | — | WO | claimed |
| WO-2001092283-A2 | COBALAMIN COMPOUNDS USEFUL AS CARDIOVASCULAR AGENTS AND AS IMAGING AGENTS | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2001-12-06 | — | — | WO | claimed |
| US-4430340-A | HEXADECYLTRIMETHYLAMMONIUM CHLORIDE, WATER, PROSTACYCLIN SODIUM SALT, DRUGS | THE UPJOHN COMPANY (US) | 1984-02-07 | — | — | US | claimed |
| EP-0005768-B1 | PHARMACEUTICAL FORMULATIONS CONTAINING PROSTAGLANDIN COMPOUNDS AND METHOD FOR THEIR PREPARATION | THE WELLCOME FOUNDATION LIMITED (GB) | 1983-08-10 | — | — | EP | claimed |
| EP-0007245-B1 | PHARMACEUTICAL COMPOSITIONS COMPRISING PROSTACYCLIN OR A PROSTACYCLIN ANALOGUE CONTAINING AN ENOL ETHER GROUP | THE UPJOHN COMPANY (US) | 1982-12-08 | — | — | EP | claimed |
| US-4335139-A | PROSTAGLANDINS | BURROUGHS WELLCOME CO. (US) | 1982-06-15 | — | — | US | claimed |
| EP-0007245-A1 | Pharmaceutical compositions comprising prostacyclin or a prostacyclin analogue containing an enol ether group | THE UPJOHN COMPANY (US) | 1980-01-23 | — | — | EP | claimed |
| EP-0005768-A1 | Pharmaceutical formulations containing prostaglandin compounds and method for their preparation | THE WELLCOME FOUNDATION LIMITED (GB) | 1979-12-12 | — | — | EP | claimed |