Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | LGMN | Q99538 | 2/20 | 0.53 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.52 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.46 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.44 |
| ▸ | PTGES | O14684 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2167020 | 0.93 | MAPT (0.64) | MAPTLGMNPDK2NOTUMMEN1 | |
| SCHEMBL2166648 | 0.83 | HRH4 (0.56) | NOTUMCHRM2DEGS1PTGES | |
| SCHEMBL988274 | 0.82 | MEN1 (0.66) | MAPTLGMNPDK2MEN1KMT2A | |
| SCHEMBL12631704 | 0.81 | NOTUM (0.49) | MAPTNOTUMALDH1A1KDM4ECHRM2 | |
| SCHEMBL12631724 | 0.81 | NOTUM (0.55) | MAPTLGMNPDK2NOTUMALDH1A1 | |
| SCHEMBL6528497 | 0.81 | LGMN (0.56) | MAPTLGMNPDK2MEN1KMT2A | |
| SCHEMBL6506137 | 0.79 | NOTUM (0.61) | MAPTLGMNPDK2NOTUMMEN1 | |
| SCHEMBL1749330 | 0.79 | MAPT (0.68) | MAPTLGMNPDK2NOTUMMEN1 | |
| SCHEMBL21542280 | 0.79 | NOTUM (0.62) | MAPTPDK2NOTUMMEN1KMT2A | |
| SCHEMBL15850037 | 0.79 | MAPT (0.71) | MAPTLGMNPDK2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2069316-A1 | 2,4-DIAMINOQUINAZOLINES FOR SPINAL MUSCULAR ATROPHY | Families of Spinal Muscular Atrophy (US) | 2009-06-17 | — | — | EP | disclosed |
| WO-2008016973-A1 | 2,4-DIAMINOQUINAZOLINES FOR SPINAL MUSCULAR ATROPHY | FAMILIES OF SPINAL MUSCULAR ATROPHY (US) | 2008-02-07 | — | — | WO | disclosed |