Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Epoprostenol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGIR known ✓ | P43119 | 6/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.98 |
| ▸ | MEN1 | O00255 | 2/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.70 |
| ▸ | PPARG | P37231 | 1/20 | 0.70 |
| ▸ | PPARD | Q03181 | 1/20 | 0.70 |
| ▸ | PPARA | Q07869 | 1/20 | 0.70 |
| ▸ | PTGER4 | P35408 | 4/20 | 0.56 |
| ▸ | TBXA2R | P21731 | 3/20 | 0.56 |
| ▸ | LMNA | P02545 | 3/20 | 0.56 |
| ▸ | PTGER1 | P34995 | 2/20 | 0.56 |
| ▸ | PTGFR | P43088 | 2/20 | 0.56 |
| ▸ | PTGER3 | P43115 | 2/20 | 0.56 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.56 |
| ▸ | SLCO2A1 | Q92959 | 1/20 | 0.56 |
| ▸ | PTGER2 | P43116 | 3/20 | 0.55 |
| ▸ | TSHR | P16473 | 3/20 | 0.55 |
| ▸ | HPGD | P15428 | 3/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.55 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Epoprostenol SCHEMBL2821707 | 1.00 | ALDH1A1 (0.98) | ALDH1A1MEN1KMT2APPARGPPARD | |
| Epoprostenol SCHEMBL705594 | 0.99 | ALDH1A1 (1.00) | ALDH1A1MEN1KMT2APPARGPPARD | |
| Epoprostenol SCHEMBL22607961 | 0.99 | ALDH1A1 (1.00) | ALDH1A1MEN1KMT2APPARGPPARD | |
| Epoprostenol SCHEMBL551616 | 0.99 | ALDH1A1 (1.00) | ALDH1A1MEN1KMT2APPARGPPARD | |
| Epoprostenol SCHEMBL24612535 | 0.99 | ALDH1A1 (1.00) | ALDH1A1MEN1KMT2APPARGPPARD | |
| Epoprostenol SCHEMBL24033081 | 0.99 | ALDH1A1 (1.00) | ALDH1A1MEN1KMT2APPARGPPARD | |
| Epoprostenol SCHEMBL4165739 | 0.99 | ALDH1A1 (1.00) | ALDH1A1MEN1KMT2APPARGPPARD | |
| Epoprostenol SCHEMBL24340812 | 0.99 | ALDH1A1 (1.00) | ALDH1A1MEN1KMT2APPARGPPARD | |
| Epoprostenol SCHEMBL21283002 | 0.99 | ALDH1A1 (1.00) | ALDH1A1MEN1KMT2APPARGPPARD | |
| Epoprostenol SCHEMBL16783375 | 0.99 | ALDH1A1 (1.00) | ALDH1A1MEN1KMT2APPARGPPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1399 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240282425-A1 | AUTHENTICATION METHODS AND SYSTEMS FOR DISPENSED PRESCRIPTIONS | LOW GORDON KEITH (US) | 2024-08-22 | — | — | US | claimed |
| CN-117887421-A | Ultrahigh-heat-conductivity graphene foam energy storage material and preparation method thereof | 中国空间技术研究院 | 2024-04-16 | — | — | CN | claimed |
| EP-4069826-A1 | EXTRACELLULAR VESICLES AND THEIR USES | United Therapeutics Corporation (US) | 2022-10-12 | — | — | EP | claimed |
| CN-109153660-B | Method for preparing epoprostenol sodium with enhanced stability | 奇诺因药物和化学工厂私人有限公司 | 2022-10-11 | — | — | CN | claimed |
| CN-115066491-A | Extracellular vesicles and uses thereof | 联合治疗公司 | 2022-09-16 | — | — | CN | claimed |
| US-20220211645-A1 | Maximizing Distribution and Minimizing Washout of Injectates in Bone and Method for Enhanced Aspirate Extraction | YALE UNIVERSITY | 2022-07-07 | — | — | US | claimed |
| EP-3965635-A2 | MAXIMIZING DISTRIBUTION AND MINIMIZING WASHOUT OF INJECTATES IN BONE AND METHOD FOR ENHANCED ASPIRATE EXTRACTION | Yale University (US) | 2022-03-16 | — | — | EP | claimed |
| EP-3852608-A1 | COMPOSITIONS AND METHODS FOR GLAUCOMA | Aufbau Medical Innovations Limited (IE) | 2021-07-28 | — | — | EP | claimed |
| WO-2021113299-A1 | EXTRACELLULAR VESICLES AND THEIR USES | UNITED THERAPEUTICS CORPORATION (US) | 2021-06-10 | — | — | WO | claimed |
| CN-107921202-B | Reducing leakage during refilling of implantable injection devices | 美敦力公司 | 2021-06-04 | — | — | CN | claimed |
| WO-2002026318-A1 | METHOD AND SYSTEM FOR NERVE STIMULATION AND CARDIAC SENSING PRIOR TO AND DURING A MEDICAL PROCEDURE | MEDTRONIC, INC. (US) | 2002-04-04 | — | — | WO | claimed |
| US-4430340-A | HEXADECYLTRIMETHYLAMMONIUM CHLORIDE, WATER, PROSTACYCLIN SODIUM SALT, DRUGS | THE UPJOHN COMPANY (US) | 1984-02-07 | — | — | US | claimed |
| US-4404212-A | ADMINISTERING ALONG WITH A HYDROLASE INHIBITOR; ANTICOAGULANTS | BURROUGHS WELLCOME CO. (US) | 1983-09-13 | — | — | US | claimed |
| EP-0005768-B1 | PHARMACEUTICAL FORMULATIONS CONTAINING PROSTAGLANDIN COMPOUNDS AND METHOD FOR THEIR PREPARATION | THE WELLCOME FOUNDATION LIMITED (GB) | 1983-08-10 | — | — | EP | claimed |
| US-4393063-A | SYNERGISTIC COMBINATION OF LA PROSTACYCLINE AND A PHOSPHODIESTERASE INHIBITOR | BURROUGHS WELLCOME CO. (US) | 1983-07-12 | — | — | US | claimed |
| EP-0007245-B1 | PHARMACEUTICAL COMPOSITIONS COMPRISING PROSTACYCLIN OR A PROSTACYCLIN ANALOGUE CONTAINING AN ENOL ETHER GROUP | THE UPJOHN COMPANY (US) | 1982-12-08 | — | — | EP | claimed |
| US-4337254-A | ANTICOAGULANTS COMPRISING A PROSTACYCLIN AND A PHOSPHODIESTERASE INHIBITOR; PREVENTING LOWERING OF BLOOD PRESSURE | BURROUGHS WELLCOME CO. (US) | 1982-06-29 | — | — | US | claimed |
| US-4335139-A | PROSTAGLANDINS | BURROUGHS WELLCOME CO. (US) | 1982-06-15 | — | — | US | claimed |
| EP-0007245-A1 | Pharmaceutical compositions comprising prostacyclin or a prostacyclin analogue containing an enol ether group | THE UPJOHN COMPANY (US) | 1980-01-23 | — | — | EP | claimed |
| EP-0005768-A1 | Pharmaceutical formulations containing prostaglandin compounds and method for their preparation | THE WELLCOME FOUNDATION LIMITED (GB) | 1979-12-12 | — | — | EP | claimed |