Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR9 | Q9NR96 | 3/20 | 0.38 |
| ▸ | TLR8 | Q9NR97 | 3/20 | 0.38 |
| ▸ | TLR7 | Q9NYK1 | 3/20 | 0.38 |
| ▸ | TLR4 | O00206 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 8/20 | 0.37 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.35 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.35 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.34 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4141352 | 0.85 | FFAR4 (0.48) | HRH3FFAR4 | |
| SCHEMBL14027061 | 0.82 | RET (0.41) | TLR9TLR8TLR7 | |
| SCHEMBL4130708 | 0.82 | HRH3 (0.43) | TLR9TLR8TLR7TLR4HRH3 | |
| SCHEMBL4136516 | 0.81 | HRH3 (0.47) | HRH3FFAR4 | |
| SCHEMBL4935121 | 0.80 | HRH3 (0.41) | TLR9TLR8TLR7TLR4HRH3 | |
| SCHEMBL4136337 | 0.79 | HRH3 (0.44) | TLR9TLR8TLR7TLR4HRH3 | |
| SCHEMBL4928014 | 0.79 | HRH3 (0.46) | TLR9TLR8TLR7HRH3ADRA1A | |
| SCHEMBL4140025 | 0.79 | SCD (0.40) | HRH3 | |
| SCHEMBL4131497 | 0.78 | HRH3 (0.44) | TLR9TLR8TLR7HRH3KDM2B | |
| SCHEMBL1744283 | 0.76 | TLR9 (0.42) | TLR9TLR8TLR7TLR4HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2021004-A2 | SUBSTITUTED AZASPIRO DERIVATIVES | NEUROGEN CORPORATION (US) | 2009-02-11 | — | — | EP | disclosed |
| WO-2007133561-A2 | SUBSTITUTED AZASPIRO DERIVATIVES | NEUROGEN CORPORATION (US) | 2007-11-22 | — | — | WO | disclosed |