Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.47 |
| ▸ | L3MBTL3 | Q96JM7 | 16/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 13/20 | 0.46 |
| ▸ | TP53BP1 | Q12888 | 2/20 | 0.44 |
| ▸ | MBTD1 | Q05BQ5 | 2/20 | 0.44 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.42 |
| ▸ | MMP2 | P08253 | 1/20 | 0.40 |
| ▸ | MMP13 | P45452 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4141352 | 0.96 | FFAR4 (0.48) | HRH3L3MBTL3L3MBTL1TP53BP1MBTD1 | |
| SCHEMBL4123180 | 0.89 | HRH3 (0.39) | HRH3L3MBTL3L3MBTL1TP53BP1MBTD1 | |
| SCHEMBL14027014 | 0.86 | TRIM24 (0.56) | HRH3L3MBTL3L3MBTL1TP53BP1MBTD1 | |
| SCHEMBL4142352 | 0.84 | L3MBTL3 (0.42) | HRH3L3MBTL3L3MBTL1TP53BP1MBTD1 | |
| SCHEMBL4937978 | 0.82 | L3MBTL3 (0.40) | HRH3L3MBTL3L3MBTL1TP53BP1MBTD1 | |
| SCHEMBL4135765 | 0.82 | L3MBTL3 (0.70) | HRH3L3MBTL3L3MBTL1TP53BP1MBTD1 | |
| SCHEMBL4129096 | 0.82 | HRH3 (0.44) | HRH3L3MBTL3L3MBTL1TP53BP1MBTD1 | |
| SCHEMBL4135581 | 0.81 | TLR9 (0.38) | HRH3FFAR4 | |
| SCHEMBL4130771 | 0.81 | ALDH1A1 (0.42) | HRH3FFAR4 | |
| SCHEMBL4130526 | 0.81 | L3MBTL3 (0.68) | HRH3L3MBTL3L3MBTL1TP53BP1MBTD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2021004-A2 | SUBSTITUTED AZASPIRO DERIVATIVES | NEUROGEN CORPORATION (US) | 2009-02-11 | — | — | EP | claimed |
| WO-2007133561-A2 | SUBSTITUTED AZASPIRO DERIVATIVES | NEUROGEN CORPORATION (US) | 2007-11-22 | — | — | WO | claimed |
| EP-2021004-A2 | SUBSTITUTED AZASPIRO DERIVATIVES | NEUROGEN CORPORATION (US) | 2009-02-11 | — | — | EP | disclosed |
| WO-2007133561-A2 | SUBSTITUTED AZASPIRO DERIVATIVES | NEUROGEN CORPORATION (US) | 2007-11-22 | — | — | WO | disclosed |