Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 6/20 | 0.76 |
| ▸ | EPHX1 | P07099 | 12/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1064217 | 0.93 | EPHX1 (0.77) | EPHX2EPHX1 | |
| SCHEMBL15224137 | 0.91 | EPHX2 (0.66) | EPHX2EPHX1KDM4EALDH1A1 | |
| SCHEMBL6872555 | 0.91 | EPHX2 (0.66) | EPHX2EPHX1KDM4EALDH1A1 | |
| SCHEMBL1065092 | 0.86 | EPHX2 (1.00) | EPHX2EPHX1KDM4EALDH1A1 | |
| SCHEMBL19420509 | 0.85 | EPHX1 (0.86) | EPHX2EPHX1KDM4EALDH1A1 | |
| SCHEMBL9750349 | 0.85 | EPHX1 (0.86) | EPHX2EPHX1KDM4EALDH1A1 | |
| SCHEMBL5596684 | 0.84 | EPHX1 (0.68) | EPHX2EPHX1KDM4EALDH1A1 | |
| SCHEMBL15224138 | 0.84 | EPHX1 (0.68) | EPHX2EPHX1KDM4EALDH1A1 | |
| SCHEMBL7985553 | 0.81 | EPHX2 (0.68) | EPHX2EPHX1 | |
| SCHEMBL1193592 | 0.81 | EPHX1 (0.97) | EPHX2EPHX1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1940785-A2 | ACYCLIC 1,4-DIAMINES AND USES THEREOF | SmithKline Beecham Corporation (US) | 2008-07-09 | — | — | EP | claimed |
| WO-2007030761-A2 | ACYCLIC 1,4-DIAMINES AND USES THEREOF | SMITHKLINE BEECHAM CORPORATION (US) | 2007-03-15 | — | — | WO | claimed |
| US-20090105259-A1 | Acyclic 1,4-Diamines and Uses Thereof | SMITHKLINE BEECHAM CORPORATION | 2009-04-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090105259-A1 | Acyclic 1,4-Diamines and Uses Thereof | TRPV4, TRPC4, TRPV1 | EPHX2 2285/4885EPHX1 1948/4885KDM4E 1551/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.