Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKB | Q96GD4 | 8/20 | 0.68 |
| ▸ | FLT3 | P36888 | 10/20 | 0.66 |
| ▸ | FLT4 | P35916 | 6/20 | 0.66 |
| ▸ | KDR | P35968 | 6/20 | 0.66 |
| ▸ | KIT | P10721 | 5/20 | 0.66 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.64 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.61 |
| ▸ | TLK2 | Q86UE8 | 1/20 | 0.61 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.59 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.55 |
| ▸ | AURKA | O14965 | 1/20 | 0.54 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.54 |
| ▸ | AURKC | Q9UQB9 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4136534 | 0.87 | TLK2 (0.66) | AURKBFLT3FLT4KDRKIT | |
| SCHEMBL3599506 | 0.84 | FLT3 (0.77) | AURKBFLT3FLT4KDRKIT | |
| SCHEMBL3599504 | 0.84 | FLT3 (0.77) | AURKBFLT3FLT4KDRKIT | |
| SCHEMBL3603444 | 0.82 | FLT3 (0.80) | AURKBFLT3FLT4KDRKIT | |
| SCHEMBL3603441 | 0.82 | FLT3 (0.80) | AURKBFLT3FLT4KDRKIT | |
| SCHEMBL15328123 | 0.81 | AURKB (1.00) | AURKBFLT3FLT4KDRKIT | |
| SCHEMBL15328125 | 0.81 | AURKB (1.00) | AURKBFLT3FLT4KDRKIT | |
| SCHEMBL27781584 | 0.79 | FLT3 (0.57) | AURKBFLT3FLT4KDRKIT | |
| SCHEMBL15328030 | 0.78 | FLT3 (1.00) | AURKBFLT3FLT4KDRKIT | |
| SCHEMBL18060032 | 0.78 | FLT3 (1.00) | AURKBFLT3FLT4KDRKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101056632-B | Compounds and compositions as protein kinase inhibitors | IRM LLC (BM) | 2011-12-07 | — | — | CN | claimed |
| EP-1814545-A4 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2009-06-10 | — | — | EP | claimed |
| US-20080221192-A1 | Compounds and Compositions as Protein Kinase Inhibitors | IRM LLC (BM) | 2008-09-11 | — | — | US | claimed |
| EP-1814545-A2 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM, LLC (BM) | 2007-08-08 | — | — | EP | claimed |
| WO-2006052936-A2 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2006-05-18 | — | — | WO | claimed |
| CN-101056632-B | Compounds and compositions as protein kinase inhibitors | IRM LLC (BM) | 2011-12-07 | — | — | CN | disclosed |
| EP-1814545-A4 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2009-06-10 | — | — | EP | disclosed |
| US-20080221192-A1 | Compounds and Compositions as Protein Kinase Inhibitors | IRM LLC (BM) | 2008-09-11 | — | — | US | disclosed |
| EP-1814545-A2 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM, LLC (BM) | 2007-08-08 | — | — | EP | disclosed |
| WO-2006052936-A2 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2006-05-18 | — | — | WO | disclosed |
| CN-1151187-A | Subtilisin 309 variants having decreased absorption and increased hydrolysis | PROCTER & GAMBLE (US) | 1997-06-04 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080221192-A1 | Compounds and Compositions as Protein Kinase Inhibitors | BMX, FRK, PTK2B | AURKB 164/4885FLT3 93/4885FLT4 323/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.