Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 18/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 7/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 7/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.43 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.40 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.40 |
| ▸ | PDE6C | P51160 | 1/20 | 0.40 |
| ▸ | TERT | O14746 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | PDE1A | P54750 | 1/20 | 0.36 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.36 |
| ▸ | MTOR | P42345 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4901618 | 0.90 | PDE5A (0.41) | PDE5AHDAC1HDAC6HDAC2PDE3B | |
| SCHEMBL4128912 | 0.89 | PDE5A (0.41) | PDE5AHDAC1HDAC6HDAC2PDE3B | |
| SCHEMBL4901484 | 0.87 | PDE5A (0.42) | PDE5AHDAC1HDAC6HDAC2PDE3B | |
| SCHEMBL4892978 | 0.85 | PDE5A (0.45) | PDE5AHDAC1HDAC6HDAC2PDE3B | |
| SCHEMBL4905752 | 0.85 | PDE5A (0.41) | PDE5AHDAC1HDAC6HDAC2PDE3B | |
| SCHEMBL4901853 | 0.85 | PDE5A (0.40) | PDE5AHDAC1HDAC6HDAC2PDE3B | |
| SCHEMBL8039488 | 0.84 | PDE5A (0.39) | PDE5AHDAC1HDAC6HDAC2PDE3B | |
| SCHEMBL4123059 | 0.81 | PDE5A (0.34) | PDE5AHDAC1HDAC6HDAC2PDE3B | |
| SCHEMBL4903686 | 0.80 | KDM4E (0.37) | MEN1ALDH1A1KMT2A | |
| SCHEMBL4128439 | 0.80 | PDE5A (0.42) | PDE5AHDAC1HDAC6HDAC2PDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009071706-A1 | PYRAZOLEPYRIMIDINE COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE & INFLAMMATORY DISEASES | GALAPAGOS NV (BE) | 2009-06-11 | — | — | WO | disclosed |
| WO-2009071706-A1 | PYRAZOLEPYRIMIDINE COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE & INFLAMMATORY DISEASES | GALAPAGOS NV (BE) | 2009-06-11 | — | — | WO | disclosed |