Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 8/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | TPH1 | P17752 | 2/20 | 0.33 |
| ▸ | TPH2 | Q8IWU9 | 2/20 | 0.33 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.33 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.33 |
| ▸ | PDE6C | P51160 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 5/20 | 0.32 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.32 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.32 |
| ▸ | PIK3C3 | Q8NEB9 | 3/20 | 0.32 |
| ▸ | PRKDC | P78527 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | TTK | P33981 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4128912 | 0.91 | PDE5A (0.41) | PDE5AHDAC1HDAC6HDAC2PDE6C | |
| SCHEMBL4133677 | 0.89 | TPH1 (0.33) | TPH1TPH2HCRTR1HCRTR2ATM | |
| SCHEMBL8032543 | 0.85 | HSP90AA1 (0.35) | HCRTR1HCRTR2ATMPIK3C3PRKDC | |
| SCHEMBL8032549 | 0.83 | PDE5A (0.36) | PDE5AHDAC1HDAC6HDAC2PDE6C | |
| SCHEMBL4128842 | 0.81 | KDM4E (0.35) | TPH1TPH2HCRTR1HCRTR2ATM | |
| SCHEMBL4136646 | 0.81 | PDE5A (0.43) | PDE5AHDAC1HDAC6HDAC2PDE6C | |
| SCHEMBL8037857 | 0.80 | PDE5A (0.42) | PDE5AHDAC1HDAC6HDAC2PDE6C | |
| SCHEMBL8039488 | 0.79 | PDE5A (0.39) | PDE5AHDAC1HDAC6HDAC2PDE6C | |
| SCHEMBL4901484 | 0.79 | PDE5A (0.42) | PDE5AHDAC1HDAC6HDAC2PDE6C | |
| SCHEMBL4901618 | 0.77 | PDE5A (0.41) | PDE5AHDAC1HDAC6HDAC2PDE6C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009071706-A1 | PYRAZOLEPYRIMIDINE COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE & INFLAMMATORY DISEASES | GALAPAGOS NV (BE) | 2009-06-11 | — | — | WO | disclosed |