Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | PDE4A | P27815 | 1/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.44 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.44 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.42 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.42 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.42 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.42 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 2/20 | 0.39 |
| ▸ | HTR2C | P28335 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4136851 | 1.00 | KDM4E (0.54) | KDM4ESMN1; SMN2CYP1A2LMNAPDE4A | |
| SCHEMBL4130521 | 0.87 | KDM4E (0.72) | KDM4ESMN1; SMN2CYP1A2LMNAPDE4A | |
| SCHEMBL4130518 | 0.87 | KDM4E (0.72) | KDM4ESMN1; SMN2CYP1A2LMNAPDE4A | |
| SCHEMBL4131419 | 0.87 | KDM4E (0.54) | KDM4ESMN1; SMN2CYP1A2LMNAPDE4A | |
| SCHEMBL11748790 | 0.85 | KDM4E (0.53) | KDM4ESMN1; SMN2CYP1A2LMNAPDE4A | |
| SCHEMBL4131074 | 0.84 | KDM4E (0.74) | KDM4ESMN1; SMN2CYP1A2LMNAPDE4A | |
| SCHEMBL4131070 | 0.84 | KDM4E (0.74) | KDM4ESMN1; SMN2CYP1A2LMNAPDE4A | |
| SCHEMBL4129090 | 0.83 | KDM4E (0.48) | KDM4ESMN1; SMN2CYP1A2LMNAPDE4A | |
| SCHEMBL4129093 | 0.83 | KDM4E (0.48) | KDM4ESMN1; SMN2CYP1A2LMNAPDE4A | |
| SCHEMBL5442506 | 0.82 | LMNA (0.51) | KDM4ESMN1; SMN2LMNAGABRA1GABRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090111760-A1 | MACROLONE COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2009-04-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090111760-A1 | MACROLONE COMPOUNDS | CYP51A1, MRPL21, MYD88 | KDM4E 3897/4885SMN1; SMN2 2560/4885CYP1A2 146/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.