SCHEMBL4139014

SCHEMBL4139014

Cn1nc(C(C)(C)C)cc1NC(=O)C(F)(F)F

nearest known ligand 0.56

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
CNR2 P34972 1/20 0.56
MAPK14 Q16539 15/20 0.56
MAPT P10636 2/20 0.56
LMNA P02545 2/20 0.56
MAPK13 O15264 2/20 0.55
MAPK11 Q15759 2/20 0.55
MAPK12 P53778 1/20 0.55
KDM4E B2RXH2 1/20 0.50
GRN P28799 1/20 0.50
SORT1 Q99523 1/20 0.50
RAF1 P04049 1/20 0.48
ERBB2 P04626 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1465671 0.87 MAPK14 (0.62) CNR2MAPK14MAPTLMNAMAPK13
SCHEMBL9892358 0.87 CNR2 (0.59) CNR2MAPK14MAPTLMNAMAPK13
SCHEMBL1699062 0.83 MAPK14 (0.61) CNR2MAPK14MAPTLMNAMAPK13
SCHEMBL284059 0.83 MAPK14 (0.45) CNR2MAPK14MAPTLMNAMAPK13
SCHEMBL7112019 0.81 MAPK14 (0.63) CNR2MAPK14MAPTLMNAMAPK13
SCHEMBL476143 0.81 CNR2 (0.51) CNR2MAPK14MAPTLMNA
SCHEMBL1621020 0.80 CNR2 (0.67) CNR2MAPK14MAPTLMNAMAPK13
SCHEMBL31034603 0.80 CDK8 (0.62) CNR2MAPK14MAPTLMNAMAPK13
SCHEMBL283286 0.80 CNR1 (0.56) CNR2MAPK14
SCHEMBL1621508 0.79 CNR2 (0.65) CNR2MAPK14MAPTLMNAMAPK13

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090192192-A1 INHIBITORS OF BIOFILM FORMATION OF GRAM-POSITIVE AND GRAM-NEGATIVE BACTERIA TOUCH BIONICS LIMITED (GB) 2009-07-30 US disclosed
US-20090192192-A1 INHIBITORS OF BIOFILM FORMATION OF GRAM-POSITIVE AND GRAM-NEGATIVE BACTERIA TOUCH BIONICS LIMITED (GB) 2009-07-30 US disclosed
US-20090192192-A1 INHIBITORS OF BIOFILM FORMATION OF GRAM-POSITIVE AND GRAM-NEGATIVE BACTERIA TOUCH BIONICS LIMITED (GB) 2009-07-30 US disclosed
WO-2009077844-A2 INHIBITORS OF BIOFILM FORMATION OF GRAM-POSITIVE AND GRAM-NEGATIVE BACTERIA QUONOVA LLC (US) 2009-06-25 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090192192-A1 INHIBITORS OF BIOFILM FORMATION OF GRAM-POSITIVE AND GRAM-NEGATIVE BACTERIA PGLS, TFPI, Q6ZSR9 CNR2 2632/4885MAPK14 1554/4885MAPT 3184/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.