Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 6/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 5/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.39 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.38 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.36 |
| ▸ | LATS1 | O95835 | 1/20 | 0.35 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.35 |
| ▸ | NAMPT | P43490 | 1/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4139793 | 1.00 | CYP11B2 (0.39) | CYP11B2HRH3CYP11B1CYP1A2CYP3A4 | |
| SCHEMBL4140206 | 0.88 | HRH3 (0.40) | CYP11B2HRH3CYP11B1CYP1A2CYP3A4 | |
| SCHEMBL4142343 | 0.88 | HRH3 (0.40) | CYP11B2HRH3CYP11B1CYP1A2CYP3A4 | |
| SCHEMBL4135895 | 0.87 | CYP11B1 (0.40) | CYP11B2HRH3CYP11B1CYP1A2CYP3A4 | |
| SCHEMBL4142298 | 0.86 | HRH3 (0.39) | HRH3CYP1A2CYP3A4KCNH2CYP2C9 | |
| SCHEMBL4136847 | 0.86 | HRH3 (0.39) | HRH3KCNH2DRD2 | |
| SCHEMBL4141039 | 0.86 | HRH3 (0.45) | CYP11B2HRH3CYP11B1CYP3A4KCNH2 | |
| SCHEMBL3323501 | 0.86 | CYP11B1 (0.57) | CYP11B2CYP11B1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL3324853 | 0.86 | CYP11B1 (0.57) | CYP11B2CYP11B1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL3323503 | 0.86 | CYP11B1 (0.57) | CYP11B2CYP11B1CYP1A2CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090163482-A1 | TETRALINES ANTAGONISTS OF THE H-3 RECEPTOR | MCHARDY STANTON FURST | 2009-06-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090163482-A1 | TETRALINES ANTAGONISTS OF THE H-3 RECEPTOR | HRH3, HRH4, HRH1 | CYP11B2 745/4885HRH3 1/4885CYP11B1 810/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.