⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6645610 | 0.92 | — | — | |
| SCHEMBL2338 | 0.63 | — | — | |
| SCHEMBL11473398 | 0.61 | TRIM24 (0.40) | — | |
| SCHEMBL9415911 | 0.61 | TRIM24 (0.40) | — | |
| SCHEMBL3882820 | 0.61 | TRIM24 (0.40) | — | |
| SCHEMBL1023703 | 0.61 | — | — | |
| SCHEMBL2011152 | 0.60 | — | — | |
| SCHEMBL358786 | 0.58 | — | — | |
| SCHEMBL77532 | 0.57 | — | — | |
| SCHEMBL367684 | 0.57 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 45 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1882529-A | Histone deacetylase inhibitors | METHYLGENE INC (CA) | 2006-12-20 | — | — | CN | claimed |
| CN-1245381-C | Phenylglycine derivatives | HOFFMANN LA ROCHE (CH) | 2006-03-15 | — | — | CN | claimed |
| CN-1642948-A | Piperazinyl-, piperidinyl-and morpholinyl derivatives as novel histone deacetylase inhibitors | JANSSEN PHARMACEUTICA NV (BE) | 2005-07-20 | — | — | CN | claimed |
| EP-1442039-A1 | PYRIMIDO (4,5-B) INDOLE DERIVATIVES | Bayer HealthCare AG (DE) | 2004-08-04 | — | — | EP | claimed |
| WO-2003037898-A1 | PYRIMIDO [4,5-B] INDOLE DERIVATIVES | BAYER HEALTHCARE AG (DE) | 2003-05-08 | — | — | WO | claimed |
| CN-110343098-A | A kind of furodiazole compound and preparation method thereof, pharmaceutical composition and purposes | 中国科学院上海药物研究所 | 2019-10-18 | — | — | CN | disclosed |
| CN-105814022-B | Condensed bicyclic heteroaromatic derivative as TNF active regulators | UCB生物制药私人有限公司 | 2018-09-28 | — | — | CN | disclosed |
| CN-105814059-B | Imidazo pyrimidine derivatives as TNF active regulators | UCB生物制药私人有限公司 | 2018-04-03 | — | — | CN | disclosed |
| CN-105814046-B | Imidazopyridine derivatives as TNF active regulators | UCB生物制药私人有限公司 | 2018-01-30 | — | — | CN | disclosed |
| CN-105814061-B | Imidazopyridazine derivative as TNF active regulators | UCB生物制药私人有限公司 | 2018-01-26 | — | — | CN | disclosed |
| CN-105814052-B | Imidazopyridine derivatives as TNF active regulators | UCB生物制药私人有限公司 | 2018-01-12 | — | — | CN | disclosed |
| CN-105814059-A | Imidazopyrimidine derivatives as modulators of TNF activity | UCB生物制药私人有限公司 | 2016-07-27 | — | — | CN | disclosed |
| EP-1373262-A2 | AZACYCLOALKYL SUBSTITUTED ACETIC ACID DERIVATIVES FOR USE AS MMP INHIBITORS | Novartis AG (CH) | 2004-01-02 | — | — | EP | disclosed |
| WO-2003066061-A1 | USE OF PDE5 INHIBITORS SUCH AS SILDENAFIL IN THE TREATMENT OF POLYCYSTIC OVARY SYNDROME | PFIZER LIMITED (GB) | 2003-08-14 | — | — | WO | disclosed |
| WO-2003050062-A2 | PRODUCTION OF CHIRALLY PURE α-AMINO ACIDS ADN N-SULFONYL α-AMINO ACIDS | WYETH (US) | 2003-06-19 | — | — | WO | disclosed |
| WO-2003037898-A1 | PYRIMIDO [4,5-B] INDOLE DERIVATIVES | BAYER HEALTHCARE AG (DE) | 2003-05-08 | — | — | WO | disclosed |
| WO-2002072577-A2 | AZACYCLOALKYL SUBSTITUTED ACETIC ACID DERIVATIVES FOR USE AS MMP INHIBITORS. | NOVARTIS AG (CH) | 2002-09-19 | — | — | WO | disclosed |
| US-5965570-A | PHARMACEUTICAL COMPOSITIONS FOR INHIBITING THE ABNORMAL GROWTH OF CELLS; ADMINISTERING TO INHIBIT TUMOR CELLS WHEREIN THE RAS PROTEIN IS ACTIVATED AS A RESULT OF ONCOGENIC MUTATION IN GENES OTHER THAN THE RAS GENE | SCHERING CORPORATION (US) | 1999-10-12 | — | — | US | disclosed |
| EP-0931078-A1 | NOVEL TRICYCLIC PIPERIDINYL COMPOUNDS USEFUL AS INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | SCHERING CORPORATION (US) | 1999-07-28 | — | — | EP | disclosed |
| WO-1998011098-A1 | NOVEL TRICYCLIC PIPERIDINYL COMPOUNDS USEFUL AS INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | SCHERING CORPORATION (US) | 1998-03-19 | — | — | WO | disclosed |