Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.34 |
| ▸ | PDE5A | O76074 | 5/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4131778 | 0.91 | NPSR1 (0.36) | ALDH1A1NPSR1MAPTSMN1; SMN2POLB | |
| SCHEMBL8042659 | 0.73 | KDM4E (0.37) | ALDH1A1NPSR1MAPTSMN1; SMN2POLB | |
| SCHEMBL8045132 | 0.73 | KDM4E (0.41) | ALDH1A1NPSR1MAPTSMN1; SMN2POLB | |
| SCHEMBL4132580 | 0.73 | KDM4E (0.35) | ALDH1A1NPSR1MAPTSMN1; SMN2POLB | |
| SCHEMBL8034133 | 0.73 | KDM4E (0.36) | ALDH1A1NPSR1MAPTSMN1; SMN2POLB | |
| SCHEMBL8033607 | 0.73 | KDM4E (0.36) | ALDH1A1NPSR1MAPTSMN1; SMN2POLB | |
| SCHEMBL3995952 | 0.72 | KDM4E (0.39) | ALDH1A1NPSR1MAPTSMN1; SMN2POLB | |
| SCHEMBL8049123 | 0.72 | KDM4E (0.37) | ALDH1A1NPSR1MAPTSMN1; SMN2POLB | |
| SCHEMBL4897525 | 0.70 | KDM4E (0.44) | ALDH1A1NPSR1MAPTSMN1; SMN2POLB | |
| SCHEMBL4127434 | 0.70 | KDM4E (0.35) | ALDH1A1NPSR1MAPTSMN1; SMN2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009071707-A1 | NOVEL COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE & INFLAMMATORY DISEASES | GALAPAGOS NV (BE) | 2009-06-11 | — | — | WO | disclosed |