Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4132580 | 0.94 | KDM4E (0.35) | KDM4EALDH1A1NPSR1MAPTSMN1; SMN2 | |
| SCHEMBL4139405 | 0.91 | KDM4E (0.34) | KDM4EALDH1A1NPSR1MAPTSMN1; SMN2 | |
| SCHEMBL8045132 | 0.89 | KDM4E (0.41) | KDM4EALDH1A1NPSR1MAPTSMN1; SMN2 | |
| SCHEMBL4117716 | 0.89 | SIGMAR1 (0.33) | KDM4EALDH1A1NPSR1MAPTSMN1; SMN2 | |
| SCHEMBL8043252 | 0.89 | KDM4E (0.36) | KDM4EALDH1A1NPSR1MAPTSMN1; SMN2 | |
| SCHEMBL8042867 | 0.88 | KDM4E (0.33) | KDM4EALDH1A1NPSR1MAPTSMN1; SMN2 | |
| SCHEMBL4123024 | 0.88 | ALDH1A1 (0.36) | KDM4EALDH1A1NPSR1MAPTSMN1; SMN2 | |
| SCHEMBL8049123 | 0.87 | KDM4E (0.37) | KDM4EALDH1A1NPSR1MAPTSMN1; SMN2 | |
| SCHEMBL4134627 | 0.86 | MAPT (0.34) | KDM4EALDH1A1NPSR1MAPTPOLB | |
| SCHEMBL3995952 | 0.85 | KDM4E (0.39) | KDM4EALDH1A1NPSR1MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009071707-A1 | NOVEL COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE & INFLAMMATORY DISEASES | GALAPAGOS NV (BE) | 2009-06-11 | — | — | WO | disclosed |