Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.47 |
| ▸ | MANBA | O00462 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | THPO | P40225 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | GLB1 | P16278 | 1/20 | 0.32 |
| ▸ | MGAM | O43451 | 1/20 | 0.30 |
| ▸ | CA1 | P00915 | 1/20 | 0.30 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13106543 | 1.00 | LMNA (0.47) | LMNAHIF1AMANBATHRBCYP1A2 | |
| SCHEMBL19146568 | 1.00 | LMNA (0.47) | LMNAHIF1AMANBATHRBCYP1A2 | |
| SCHEMBL4131205 | 1.00 | LMNA (0.47) | LMNAHIF1AMANBATHRBCYP1A2 | |
| SCHEMBL19146746 | 1.00 | LMNA (0.47) | LMNAHIF1AMANBATHRBCYP1A2 | |
| SCHEMBL2159235 | 1.00 | LMNA (0.47) | LMNAHIF1AMANBATHRBCYP1A2 | |
| SCHEMBL23288111 | 1.00 | LMNA (0.47) | LMNAHIF1AMANBATHRBCYP1A2 | |
| SCHEMBL19129777 | 1.00 | LMNA (0.47) | LMNAHIF1AMANBATHRBCYP1A2 | |
| SCHEMBL19129720 | 1.00 | LMNA (0.47) | LMNAHIF1AMANBATHRBCYP1A2 | |
| SCHEMBL12396147 | 1.00 | LMNA (0.47) | LMNAHIF1AMANBATHRBCYP1A2 | |
| SCHEMBL13772994 | 0.89 | MANBA (0.36) | LMNAHIF1AMANBATHRBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090182154-A1 | Combinatorial library approach to iminocyclitols with biological activity | UNITED THERAPEUTICS CORPORATION | 2009-07-16 | — | — | US | disclosed |
| US-20070088164-A1 | Combinatorial library approach to iminocyclitols with biological activity | MORIARITY ROBERT M | 2007-04-19 | — | — | US | disclosed |
| US-5153325-A | Catalytic hydrogenation of protected azido-L-gulo-heptulose with platinum/iv/ oxide, deprotection of iminoheptitol by hydrolysis | MONSANTO COMPANY (US) | 1992-10-06 | — | — | US | disclosed |
| US-5096909-A | Imino-trideoxy-glycero-gluco heptitol | MONSANTO COMPANY (US) | 1992-03-17 | — | — | US | disclosed |
| US-5017704-A | 2,6-imino-2,6,7-trideoxy-D-glycero-D-gluco heptitol | MONSANTO COMPANY (US) | 1991-05-21 | — | — | US | disclosed |
| EP-0409812-A2 | Fucosidase inhibitor | MONSANTO COMPANY (US) | 1991-01-23 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070088164-A1 | Combinatorial library approach to iminocyclitols with biological activity | PAICS, IMPDH1, UGCG | LMNA 843/4885HIF1A 519/4885MANBA 25/4885 |
| US-20090182154-A1 | Combinatorial library approach to iminocyclitols with biological activity | PAICS, IMPDH1, UGCG | LMNA 843/4885HIF1A 519/4885MANBA 25/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.