Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 20/20 | 0.43 |
| ▸ | THRB | P10828 | 3/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5236124 | 0.76 | TGFBR1 (0.67) | TGFBR1THRBMAPK14 | |
| SCHEMBL415073 | 0.69 | TGFBR1 (0.63) | TGFBR1THRBMAPK14 | |
| SCHEMBL415072 | 0.67 | TGFBR1 (0.60) | TGFBR1THRBMAPK14 | |
| SCHEMBL413520 | 0.67 | TGFBR1 (0.69) | TGFBR1THRBMAPK14 | |
| SCHEMBL411445 | 0.65 | TGFBR1 (0.67) | TGFBR1THRBMAPK14 | |
| SCHEMBL16297280 | 0.65 | TGFBR1 (0.68) | TGFBR1THRBMAPK14 | |
| SCHEMBL4482674 | 0.62 | TGFBR1 (0.66) | TGFBR1THRBMAPK14 | |
| SCHEMBL4479782 | 0.62 | TGFBR1 (0.65) | TGFBR1THRBMAPK14 | |
| SCHEMBL414167 | 0.61 | TGFBR1 (0.87) | TGFBR1THRBMAPK14 | |
| SCHEMBL413677 | 0.60 | TGFBR1 (0.77) | TGFBR1THRBMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014201133-A1 | COMPOSITIONS AND METHODS FOR IMPROVING INDUCED NEURON GENERATION | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2014-12-18 | — | — | WO | disclosed |
| US-20140120621-A1 | TGF-BETA RECEPTOR INHIBITORS TO ENHANCE DIRECT REPROGRAMMING | THE GENERAL HOSPITAL CORPORATION (US) | 2014-05-01 | — | — | US | disclosed |
| US-8603818-B1 | TGF-beta receptor inhibitors to enhance direct reprogramming | THE GENERAL HOSPITAL CORPORATION (US) | 2013-12-10 | — | — | US | disclosed |
| US-8298825-B1 | TGF-beta receptor inhibitors to enhance direct reprogramming | THE GENERAL HOSPITAL CORPORATION (US) | 2012-10-30 | — | — | US | disclosed |
| US-20120021519-A1 | EFFICIENT INDUCTION OF PLURIPOTENT STEM CELLS USING SMALL MOLECULE COMPOUNDS | PRESIDENTS AND FELLOWS OF HARVARD COLLEGE (US) | 2012-01-26 | — | — | US | disclosed |