SCHEMBL4144049

SCHEMBL4144049

CCCCOc1ccc(/C=C2/C(=O)N(c3ccccc3)N=C2C)cc1OC

nearest known ligand 0.83

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 12/20 0.83
L3MBTL1 Q9Y468 5/20 0.83
POLB P06746 1/20 0.78
MEN1 O00255 10/20 0.68
AMY1A P0DUB6 4/20 0.68
ALDH1A1 P00352 4/20 0.67
MAPT P10636 4/20 0.67
HPGD P15428 4/20 0.67
PKM P14618 1/20 0.67
HTT P42858 1/20 0.67
THRB P10828 3/20 0.60
KDM4E B2RXH2 2/20 0.60
TDP1 Q9NUW8 2/20 0.60
LMNA P02545 1/20 0.60
SAE1 Q9UBE0 1/20 0.60
UBA2 Q9UBT2 1/20 0.60
PTGS2 P35354 1/20 0.57
GAA P10253 4/20 0.57
CYP1A2 P05177 2/20 0.56
CYP2C9 P11712 2/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4144051 1.00 KMT2A (0.83) KMT2AL3MBTL1POLBMEN1AMY1A
SCHEMBL4268975 0.83 KMT2A (0.76) KMT2AL3MBTL1POLBMEN1AMY1A
SCHEMBL4257062 0.83 KMT2A (0.76) KMT2AL3MBTL1POLBMEN1AMY1A
SCHEMBL24212685 0.80 KMT2A (0.81) KMT2AL3MBTL1POLBMEN1AMY1A
SCHEMBL28967924 0.79 KMT2A (0.66) KMT2AL3MBTL1POLBMEN1AMY1A
SCHEMBL3134918 0.78 KMT2A (0.74) KMT2AL3MBTL1POLBMEN1AMY1A
SCHEMBL3134925 0.78 KMT2A (0.74) KMT2AL3MBTL1POLBMEN1AMY1A
SCHEMBL22523764 0.77 KMT2A (0.80) KMT2AL3MBTL1POLBMEN1AMY1A
SCHEMBL3668076 0.77 KMT2A (0.65) KMT2AL3MBTL1POLBMEN1AMY1A
SCHEMBL13572441 0.77 KMT2A (0.65) KMT2AL3MBTL1POLBMEN1AMY1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1484051-B1 Use of at least one blue-light screening agent to preserve the amount of endogenous carotenoids in the skin, new blue- light screening agents, cosmetic compositions. OREAL (FR) 2013-08-21 EP claimed
US-20090074820-A1 AMINOARYLVINYL-S-TRIAZINE COMPOUNDS AND USES THEREOF L'OREAL (FR) 2009-03-19 US claimed
US-20050008588-A1 Aminoarylvinyl-s-triazine compounds and uses thereof L'OREAL (FR) 2005-01-13 US claimed
EP-1484051-A2 Use of at least one blue-light screening agent to preserve the amount of endogenous carotenoids in the skin, new blue- light screening agents, cosmetic compositions. L'OREAL (FR) 2004-12-08 EP claimed
EP-1484051-B1 Use of at least one blue-light screening agent to preserve the amount of endogenous carotenoids in the skin, new blue- light screening agents, cosmetic compositions. OREAL (FR) 2013-08-21 EP disclosed
US-20090074820-A1 AMINOARYLVINYL-S-TRIAZINE COMPOUNDS AND USES THEREOF L'OREAL (FR) 2009-03-19 US disclosed
US-20090074820-A1 AMINOARYLVINYL-S-TRIAZINE COMPOUNDS AND USES THEREOF L'OREAL (FR) 2009-03-19 US disclosed
US-20090074820-A1 AMINOARYLVINYL-S-TRIAZINE COMPOUNDS AND USES THEREOF L'OREAL (FR) 2009-03-19 US disclosed
US-20050008588-A1 Aminoarylvinyl-s-triazine compounds and uses thereof L'OREAL (FR) 2005-01-13 US disclosed
EP-1484051-A2 Use of at least one blue-light screening agent to preserve the amount of endogenous carotenoids in the skin, new blue- light screening agents, cosmetic compositions. L'OREAL (FR) 2004-12-08 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050008588-A1 Aminoarylvinyl-s-triazine compounds and uses thereof TYR, AAAS, ALAD KMT2A 1215/4885L3MBTL1 2589/4885POLB 2900/4885
US-20090074820-A1 AMINOARYLVINYL-S-TRIAZINE COMPOUNDS AND USES THEREOF TYR, AAAS, ALAD KMT2A 1027/4885L3MBTL1 2611/4885POLB 3130/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.