Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 18/20 | 0.74 |
| ▸ | HRH1 | P35367 | 12/20 | 0.74 |
| ▸ | ADRA1B | P35368 | 7/20 | 0.74 |
| ▸ | ADRA1A | P35348 | 7/20 | 0.74 |
| ▸ | KCNH2 | Q12809 | 11/20 | 0.67 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | SMYD2 | Q9NRG4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2852985 | 0.86 | HRH3 (0.84) | HRH3HRH1ADRA1BADRA1AKCNH2 | |
| SCHEMBL2852984 | 0.86 | HRH3 (0.84) | HRH3HRH1ADRA1BADRA1AKCNH2 | |
| SCHEMBL2850269 | 0.85 | HRH3 (1.00) | HRH3HRH1ADRA1BADRA1AKCNH2 | |
| SCHEMBL2850271 | 0.85 | HRH3 (1.00) | HRH3HRH1ADRA1BADRA1AKCNH2 | |
| Formic Acid SCHEMBL4144418 | 0.85 | HRH3 (0.81) | HRH3HRH1ADRA1BADRA1AKCNH2 | |
| SCHEMBL2846839 | 0.81 | HRH3 (0.83) | HRH3HRH1ADRA1BADRA1AKCNH2 | |
| SCHEMBL2851067 | 0.80 | HRH3 (1.00) | HRH3HRH1ADRA1BADRA1AKCNH2 | |
| SCHEMBL13438221 | 0.77 | HRH3 (1.00) | HRH3HRH1ADRA1BADRA1AKCNH2 | |
| SCHEMBL13438225 | 0.77 | HRH3 (1.00) | HRH3HRH1ADRA1BADRA1AKCNH2 | |
| SCHEMBL2854990 | 0.77 | HRH3 (0.81) | HRH3HRH1ADRA1BADRA1AKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090181950-A1 | Histamine Receptor Antagonists Comprising an Azepin Core | GLAXO GROUP LIMITED (GB) | 2009-07-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090181950-A1 | Histamine Receptor Antagonists Comprising an Azepin Core | HRH2, HRH1, HRH4 | HRH3 4/4885HRH1 2/4885ADRA1B 175/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.