Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 4/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | GAA | P10253 | 4/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | DHODH | Q02127 | 3/20 | 0.35 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.35 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4144510 | 1.00 | MAPT (0.40) | MAPTALOX12CYP2D6ALDH1A1SMN1; SMN2 | |
| SCHEMBL13774398 | 1.00 | MAPT (0.40) | MAPTALOX12CYP2D6ALDH1A1SMN1; SMN2 | |
| SCHEMBL3768873 | 0.87 | MAPT (0.43) | MAPTALOX12ALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL3768874 | 0.87 | MAPT (0.43) | MAPTALOX12ALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL3290298 | 0.84 | KMT2A (0.39) | MAPTCYP2D6ALDH1A1MEN1KMT2A | |
| SCHEMBL4154025 | 0.84 | KMT2A (0.39) | MAPTCYP2D6ALDH1A1MEN1KMT2A | |
| SCHEMBL15085007 | 0.82 | MAPT (0.40) | MAPTALDH1A1MEN1KMT2AGAA | |
| SCHEMBL12961518 | 0.81 | MEN1 (0.41) | MAPTMEN1KMT2AGAANPSR1 | |
| SCHEMBL1430059 | 0.81 | MEN1 (0.41) | MAPTMEN1KMT2AGAANPSR1 | |
| SCHEMBL1430057 | 0.81 | MEN1 (0.41) | MAPTMEN1KMT2AGAANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090170791-A1 | MACROLONES | GLAXO SMITH KLINE ISTRAZIVACKI CENTAR ZAGREB D.O.O A CORPORATION | 2009-07-02 | — | — | US | disclosed |
| EP-1945652-A1 | MACROLONES | GLAXO GROUP LIMITED (GB) | 2008-07-23 | — | — | EP | disclosed |
| WO-2007054296-A1 | MACROLONES | GLAXO GROUP LIMITED (GB) | 2007-05-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090170791-A1 | MACROLONES | CYP51A1, MRPL21, LSS | MAPT 3813/4885ALOX12 1231/4885CYP2D6 36/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.