Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.35 |
| ▸ | MAP2K1 | Q02750 | 6/20 | 0.32 |
| ▸ | MAP2K2 | P36507 | 4/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | PTPRC | P08575 | 1/20 | 0.32 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.32 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.32 |
| ▸ | PTPRA | P18433 | 1/20 | 0.32 |
| ▸ | PTPRB | P23467 | 1/20 | 0.32 |
| ▸ | PTPRE | P23469 | 1/20 | 0.32 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.32 |
| ▸ | CES2 | O00748 | 1/20 | 0.31 |
| ▸ | CES1 | P23141 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.31 |
| ▸ | RAD52 | P43351 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3768873 | 1.00 | MAPT (0.43) | MAPTALOX12ACKR3MAP2K1MAP2K2 | |
| SCHEMBL13774398 | 0.87 | MAPT (0.40) | MAPTALOX12ACKR3MAP2K1MAP2K2 | |
| SCHEMBL4144510 | 0.87 | MAPT (0.40) | MAPTALOX12ACKR3MAP2K1MAP2K2 | |
| SCHEMBL4144513 | 0.87 | MAPT (0.40) | MAPTALOX12ACKR3MAP2K1MAP2K2 | |
| SCHEMBL1429997 | 0.77 | CES2 (0.38) | MAP2K1MAP2K2PTPRCPTPN2PTPN1 | |
| SCHEMBL1429996 | 0.77 | CES2 (0.38) | MAP2K1MAP2K2PTPRCPTPN2PTPN1 | |
| SCHEMBL3780772 | 0.72 | CES2 (0.38) | MAP2K1MAP2K2PTPRCPTPN2PTPN1 | |
| SCHEMBL3780775 | 0.72 | CES2 (0.38) | MAP2K1MAP2K2PTPRCPTPN2PTPN1 | |
| SCHEMBL6420342 | 0.71 | MAP2K2 (0.35) | MAP2K1MAP2K2CES2CES1 | |
| SCHEMBL6420333 | 0.71 | MAP2K2 (0.35) | MAP2K1MAP2K2CES2CES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100317624-A1 | HETEROCYCLIC UREA DERIVATIVES AND METHODS OF USE THEREOF | ASTRAZENECA AB | 2010-12-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100317624-A1 | HETEROCYCLIC UREA DERIVATIVES AND METHODS OF USE THEREOF | UROD, UMPS, SLC14A1 | MAPT 1549/4885ALOX12 3103/4885ACKR3 3766/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.