Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIT | P10721 | 1/20 | 0.48 |
| ▸ | FLT3 | P36888 | 1/20 | 0.48 |
| ▸ | KDR | P35968 | 7/20 | 0.45 |
| ▸ | CHEK1 | O14757 | 5/20 | 0.45 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.45 |
| ▸ | LCK | P06239 | 1/20 | 0.43 |
| ▸ | CDK4 | P11802 | 1/20 | 0.43 |
| ▸ | CCND1 | P24385 | 1/20 | 0.43 |
| ▸ | CCND3 | P30281 | 1/20 | 0.43 |
| ▸ | ITK | Q08881 | 1/20 | 0.41 |
| ▸ | MAP2K4 | P45985 | 2/20 | 0.40 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.39 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.39 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | BTK | Q06187 | 1/20 | 0.39 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.39 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.39 |
| ▸ | GCK | P35557 | 2/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2448984 | 0.87 | KDR (0.45) | KDRCHEK1FGFR1LCKCDK4 | |
| SCHEMBL4144286 | 0.85 | ALDH1A1 (0.49) | KDRCHEK1FGFR1LCKCDK4 | |
| SCHEMBL16576449 | 0.85 | KDR (0.59) | KITFLT3KDRCHEK1FGFR1 | |
| SCHEMBL4134957 | 0.81 | KDR (0.40) | KDRCHEK1FGFR1LCKCDK4 | |
| SCHEMBL4144602 | 0.81 | KDR (0.43) | KITFLT3KDRCHEK1FGFR1 | |
| SCHEMBL27805303 | 0.80 | KDR (0.47) | KDRCHEK1FGFR1LCKCDK4 | |
| SCHEMBL4155522 | 0.79 | NR1H2 (0.45) | KDRCHEK1FGFR1GCK | |
| SCHEMBL8212257 | 0.78 | MAP2K4 (0.56) | ITKMAP2K4 | |
| SCHEMBL27805305 | 0.75 | CHEK1 (0.43) | KDRCHEK1FGFR1PRMT5WDR77 | |
| SCHEMBL12907469 | 0.75 | JAK2 (0.53) | KDRCHEK1FGFR1CDK4CCND1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090143422-A1 | P38 INHIBITORS AND METHODS OF USE THEREOF | ARRAY BIOPHARMA INC. (US) | 2009-06-04 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090143422-A1 | P38 INHIBITORS AND METHODS OF USE THEREOF | MAPKAPK2, MAPK1, MAPK8 | KIT 2859/4885FLT3 857/4885KDR 2788/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.