Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 4/20 | 0.45 |
| ▸ | CSGALNACT1 | Q8TDX6 | 1/20 | 0.45 |
| ▸ | USP30 | Q70CQ3 | 3/20 | 0.43 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | TNF | P01375 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.40 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.40 |
| ▸ | BACE1 | P56817 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4145633 | 0.87 | DGAT1 (0.44) | DGAT1CSGALNACT1USP30DYRK2L3MBTL1 | |
| SCHEMBL3391081 | 0.84 | DGAT1 (0.53) | DGAT1CSGALNACT1MAPTSMN1; SMN2GAA | |
| SCHEMBL1761696 | 0.80 | DGAT1 (0.56) | DGAT1CSGALNACT1USP30DYRK2L3MBTL1 | |
| SCHEMBL1761868 | 0.76 | DGAT1 (0.59) | DGAT1CSGALNACT1DYRK2MAPTSMN1; SMN2 | |
| Bicarbonate SCHEMBL3388196 | 0.74 | DGAT1 (0.60) | DGAT1CSGALNACT1MAPTSMN1; SMN2GAA | |
| SCHEMBL3391083 | 0.73 | DGAT1 (0.52) | DGAT1CSGALNACT1MAPTSMN1; SMN2GAA | |
| SCHEMBL1761313 | 0.70 | SMN1; SMN2 (0.77) | DGAT1CSGALNACT1MAPTSMN1; SMN2GAA | |
| SCHEMBL3390923 | 0.70 | DGAT1 (0.54) | DGAT1CSGALNACT1MAPTSMN1; SMN2GAA | |
| SCHEMBL1762130 | 0.70 | DGAT1 (0.54) | DGAT1CSGALNACT1MAPTSMN1; SMN2GAA | |
| SCHEMBL12430212 | 0.69 | DGAT1 (0.80) | DGAT1CSGALNACT1MAPTSMN1; SMN2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1805156-A4 | PREPARATION AND USE OF BIPHENYL-4-YL-CARBONYLAMINO ACID DERIVATIVES FOR THE TREATMENT OF OBESITY | BAYER PHARMACEUTICALS CORP (US) | 2009-06-10 | — | — | EP | claimed |
| EP-1805156-A2 | PREPARATION AND USE OF BIPHENYL-4-YL-CARBONYLAMINO ACID DERIVATIVES FOR THE TREATMENT OF OBESITY | Bayer Pharmaceuticals Corporation (US) | 2007-07-11 | — | — | EP | claimed |
| WO-2006044775-A2 | PREPARATION AND USE OF BIPHENYL-4-YL-CARBONYLAMINO ACID DERIVATIVES FOR THE TREATMENT OF OBESITY | BAYER PHARMACEUTICALS CORPORATION (US) | 2006-04-27 | — | — | WO | claimed |