Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.39 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.39 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | TNF | P01375 | 1/20 | 0.37 |
| ▸ | MC4R | P32245 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.33 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | HPGDS | O60760 | 1/20 | 0.33 |
| ▸ | TACR1 | P25103 | 1/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4147272 | 0.74 | FGFR1 (0.40) | FGFR1FGFR2FGFR4FGFR3KDR | |
| SCHEMBL4146681 | 0.73 | SLC6A2 (0.41) | FGFR1FGFR2FGFR4FGFR3KDR | |
| SCHEMBL31023685 | 0.70 | TDP1 (0.44) | TDP1SLC6A2SLC6A4KDM1ATACR1 | |
| SCHEMBL31342907 | 0.67 | SLC6A2 (0.35) | SLC6A2SLC6A4CYP3A4SLC6A3 | |
| Hydrochloric Acid SCHEMBL31342872 | 0.67 | SLC6A2 (0.34) | SLC6A2SLC6A4CYP3A4SLC6A3 | |
| Hydrochloric Acid SCHEMBL31342952 | 0.66 | ACVR1B (0.32) | FGFR1FGFR2FGFR4FGFR3KDR | |
| SCHEMBL31342801 | 0.65 | SLC6A2 (0.35) | SLC6A2SLC6A4CYP3A4SMN1; SMN2SLC6A3 | |
| SCHEMBL31023843 | 0.64 | ALDH1A1 (0.40) | TDP1SLC6A2SLC6A4ALDH1A1SMN1; SMN2 | |
| SCHEMBL4153836 | 0.63 | FGFR3 (0.40) | FGFR1FGFR2FGFR4FGFR3KDR | |
| SCHEMBL4134857 | 0.62 | SLC6A2 (0.39) | FGFR1FGFR2FGFR4FGFR3KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090118270-A1 | PHOSPHODIESTERASE 4 INHIBITORS | TALAMAS FRANCISCO XAVIER | 2009-05-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090118270-A1 | PHOSPHODIESTERASE 4 INHIBITORS | PDE4A, PDE3B, PDE4B | FGFR1 2718/4885FGFR2 3727/4885FGFR4 857/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.