SCHEMBL4147281

SCHEMBL4147281

O=C(OCc1ccccc1)c1cc(C2=C(c3cc(Br)cnc3OCc3ccccc3)CCC2)ccc1F

nearest known ligand 0.47

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
PTGER1 P34995 18/20 0.47
CYP2C9 P11712 4/20 0.41
CNR1 P21554 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4149670 0.92 PTGER1 (0.51) PTGER1CYP2C9
SCHEMBL4161765 0.87 PTGER1 (0.47) PTGER1CYP2C9CNR1
SCHEMBL4154852 0.85 PTGER1 (0.54) PTGER1CYP2C9CNR1
SCHEMBL4162650 0.84 PTGER1 (0.41) PTGER1CYP2C9
SCHEMBL13696911 0.84 PTGER1 (0.51) PTGER1CYP2C9
SCHEMBL4163577 0.84 PTGER1 (0.48) PTGER1CYP2C9CNR1
SCHEMBL4150734 0.83 PTGER1 (0.47) PTGER1CYP2C9
SCHEMBL4149183 0.82 PTGER1 (0.49) PTGER1CYP2C9
SCHEMBL4170694 0.82 PTGER1 (0.37) PTGER1CYP2C9
SCHEMBL4155622 0.81 PTGER1 (0.52) PTGER1CYP2C9CNR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090227591-A1 Cyclopentene compounds GLAXO GROUP LIMITED (GB) 2009-09-10 US disclosed
US-20090227591-A1 Cyclopentene compounds GLAXO GROUP LIMITED (GB) 2009-09-10 US disclosed
US-20090227591-A1 Cyclopentene compounds GLAXO GROUP LIMITED (GB) 2009-09-10 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090227591-A1 Cyclopentene compounds C1R, CYP1B1, ADORA2B PTGER1 246/4885CYP2C9 5/4885CNR1 32/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.