⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1830737 | 0.98 | ALDH1A1 (0.37) | — | |
| SCHEMBL8710217 | 0.86 | CA12 (0.40) | — | |
| SCHEMBL437092 | 0.84 | ALDH1A1 (0.46) | — | |
| SCHEMBL28277555 | 0.84 | ALDH1A1 (0.46) | — | |
| SCHEMBL439675 | 0.84 | ALDH1A1 (0.46) | — | |
| SCHEMBL11792981 | 0.84 | ALDH1A1 (0.46) | — | |
| SCHEMBL1773954 | 0.84 | ALDH1A1 (0.46) | — | |
| Ethylene SCHEMBL11441586 | 0.81 | ALDH1A1 (0.48) | — | |
| Ethylene SCHEMBL20711015 | 0.81 | ALDH1A1 (0.48) | — | |
| SCHEMBL417312 | 0.81 | ALDH1A1 (0.53) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 48 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090170934-A1 | MANUFACTURING PROCESS FOR NO-DONATING COMPOUNDS SUCH AS NO-DONATING DICLOFENAC | NICOX SA | 2009-07-02 | — | — | US | claimed |
| US-20060141044-A1 | Pharmaceutical compositions based on diclofenac derivate | NICOX S.A. (FR) | 2006-06-29 | — | — | US | claimed |
| US-20060122402-A1 | Manufacturing process for no-donating compounds such as no-donating diclofenac | NICOX SA (FR) | 2006-06-08 | — | — | US | claimed |
| EP-1635790-A1 | PHARMACEUTICAL COMPOSITIONS BASED ON DICLOFENAC DERIVATE | Nicox S.A. (FR) | 2006-03-22 | — | — | EP | claimed |
| CN-1684940-A | Manufacturing process for NO-donating compounds such as NO-donating diclofenac | NICOX SA (FR) | 2005-10-19 | — | — | CN | claimed |
| US-20050129774-A1 | Non-donating nsaids adsorbed into carrier particles | ASTRAZENECA AB (SE) | 2005-06-16 | — | — | US | claimed |
| WO-2004112753-A1 | PHARMACEUTICAL COMPOSITIONS BASED ON DICLOFENAC DERIVATE | NICOX S.A. (FR) | 2004-12-29 | — | — | WO | claimed |
| EP-1490033-A1 | NO-DONATING NSAIDS ADSORBED INTO CARRIER PARTICLES | Nicox S.A. (FR) | 2004-12-29 | — | — | EP | claimed |
| WO-2003080029-A1 | NO-DONATING NSAIDS ADSORBED INTO CARRIER PARTICLES | ASTRAZENECA AB (SE) | 2003-10-02 | — | — | WO | claimed |
| EP-0207674-A2 | 1,4-Dihydropyridine derivatives, their preparation and their pharmaceutical use | SANKYO COMPANY LIMITED (JP) | 1987-01-07 | — | — | EP | claimed |
| US-10266511-B2 | No-releasing nitrooxy-chromene conjugates | Euclises Pharmaceuticals, Inc. (US) | 2019-04-23 | — | — | US | disclosed |
| US-20160340330-A1 | NO-RELEASING NITROOXY-CHROMENE CONJUGATES | Euclises Pharmaceuticals, Inc. | 2016-11-24 | — | — | US | disclosed |
| EP-3094333-A1 | NO-RELEASING NITROOXY-CHROMENE CONJUGATES | Euclises Pharmaceuticals, Inc. (US) | 2016-11-23 | — | — | EP | disclosed |
| WO-2015109011-A1 | NO-RELEASING NITROOXY-CHROMENE CONJUGATES | Euclises Pharmaceuticals, Inc. (US) | 2015-07-23 | — | — | WO | disclosed |
| US-20090170934-A1 | MANUFACTURING PROCESS FOR NO-DONATING COMPOUNDS SUCH AS NO-DONATING DICLOFENAC | NICOX SA | 2009-07-02 | — | — | US | disclosed |
| EP-0759899-A1 | NITRO COMPOUNDS AND THEIR COMPOSITIONS HAVING ANTI-INFLAMMATORY, ANALGESIC AND ANTI-THROMBOTIC ACITIVITIES | NICOX S.A. (FR) | 1997-03-05 | — | — | EP | disclosed |
| WO-1995030641-A1 | NITRO COMPOUNDS AND THEIR COMPOSITIONS HAVING ANTI-INFLAMMATORY, ANALGESIC AND ANTI-THROMBOTIC ACITIVITIES | NICOX S.A. (FR) | 1995-11-16 | — | — | WO | disclosed |
| EP-0623597-A1 | Pyridine derivatives, with potassium channel opening activity | Takeda Chemical Industries, Ltd. (JP) | 1994-11-09 | — | — | EP | disclosed |
| US-4992451-A | Hypotensive agents, calcium blocking agents | SANKYO COMPANY, LIMITED (JP) | 1991-02-12 | — | — | US | disclosed |
| EP-0207674-A2 | 1,4-Dihydropyridine derivatives, their preparation and their pharmaceutical use | SANKYO COMPANY LIMITED (JP) | 1987-01-07 | — | — | EP | disclosed |