Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 6/20 | 0.36 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.36 |
| ▸ | NR1I2 | O75469 | 4/20 | 0.36 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.33 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.33 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.33 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4148776 | 1.00 | KCNH2 (0.36) | KCNH2KDM2BNR1I2AKR1C3TAS2R14 | |
| SCHEMBL4159480 | 0.92 | MTNR1A (0.35) | MTNR1AMTNR1B | |
| SCHEMBL4159482 | 0.92 | MTNR1A (0.35) | MTNR1AMTNR1B | |
| SCHEMBL4148306 | 0.90 | HRH3 (0.34) | — | |
| SCHEMBL4148304 | 0.90 | HRH3 (0.34) | — | |
| SCHEMBL4152873 | 0.90 | NR1I2 (0.33) | NR1I2AKR1C3 | |
| SCHEMBL4152870 | 0.90 | NR1I2 (0.33) | NR1I2AKR1C3 | |
| SCHEMBL4144273 | 0.90 | KCNH2 (0.37) | KCNH2NR1I2AKR1C3TAS2R14MTNR1A | |
| SCHEMBL4144274 | 0.90 | KCNH2 (0.37) | KCNH2NR1I2AKR1C3TAS2R14MTNR1A | |
| SCHEMBL4143938 | 0.89 | HRH3 (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090136449-A1 | Tetracyclic Indole Derivatives as Antiviral Agents | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA (IT) | 2009-05-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090136449-A1 | Tetracyclic Indole Derivatives as Antiviral Agents | IDO1, IDO2, ZC3HAV1 | KCNH2 1467/4885KDM2B 3436/4885NR1I2 268/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.