Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Salicyl Alcohol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 1/20 | 0.59 |
| ▸ | PKM | P14618 | 2/20 | 0.50 |
| ▸ | HSPA5 | P11021 | 1/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | IAPP | P10997 | 1/20 | 0.44 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.43 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.42 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 2/20 | 0.42 |
| ▸ | CA2 | P00918 | 2/20 | 0.42 |
| ▸ | IDO1 | P14902 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Salicyl Alcohol SCHEMBL1395496 | 0.91 | AKR1B1 (0.64) | AKR1B1PKMHSPA5HIF1ACYP2D6 | |
| Salicyl Alcohol SCHEMBL28230169 | 0.89 | HSPA5 (0.62) | AKR1B1PKMHSPA5HIF1ACYP2D6 | |
| Salicyl Alcohol SCHEMBL9577921 | 0.88 | AKR1B1 (0.52) | AKR1B1PKMHSPA5HIF1ACYP2D6 | |
| Salicyl Alcohol SCHEMBL29728553 | 0.87 | AKR1B1 (0.59) | AKR1B1PKMHSPA5HIF1ACYP2D6 | |
| Salicyl Alcohol SCHEMBL9220390 | 0.86 | HSPA5 (0.59) | AKR1B1HSPA5HIF1ACYP2D6TSHR | |
| Salicyl Alcohol SCHEMBL29453973 | 0.86 | — | — | |
| Salicyl Alcohol SCHEMBL17028795 | 0.86 | HSPA5 (0.65) | AKR1B1HSPA5HIF1ACYP2D6TSHR | |
| Salicyl Alcohol SCHEMBL15639 | 0.86 | — | — | |
| Salicyl Alcohol SCHEMBL16965609 | 0.86 | AKR1B1 (0.53) | AKR1B1PKMHSPA5HIF1ACYP2D6 | |
| Acetic Acid SCHEMBL27895243 | 0.84 | AKR1B1 (0.61) | AKR1B1HSPA5HIF1ACYP2D6TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101974436-B | Lignocellulose degrading bacteria and application thereof | INST AGRI RESOURCES CAAS | 2012-10-03 | — | — | CN | disclosed |
| CN-101104745-B | Method for producing natural blue pigment | UNIV EAST CHINA SCIENCE & TECH | 2011-05-18 | — | — | CN | disclosed |
| CN-101974436-A | Lignocellulose degrading bacteria and application thereof | INST AGRI RESOURCES CAAS | 2011-02-16 | — | — | CN | disclosed |
| CN-101225404-B | Compound organic nitrogen source used for microbial fermentation | UNIV EAST CHINA SCIENCE & TECH | 2010-12-29 | — | — | CN | disclosed |
| US-20090068273-A1 | Inhalation devices for delivering phenethanolamine derivatives for the treatment of respiratory diseases | GLAXO GROUP LIMITED (GB) | 2009-03-12 | — | — | US | disclosed |
| CN-101225404-A | Compound organic nitrogen source used for microbial fermentation | UNIV EAST CHINA SCIENCE & TECH (CN) | 2008-07-23 | — | — | CN | disclosed |
| CN-101104745-A | Method for producing natural blue pigment | UNIV EAST CHINA SCIENCE & TECH (CN) | 2008-01-16 | — | — | CN | disclosed |
| EP-1497261-A1 | PHENETHANOLAMINE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 2005-01-19 | — | — | EP | disclosed |
| EP-1425001-A1 | PHENETHANOLAMINE DERIVATIVES FOR TREATMENT OF RESPIRATORY DISEASES | GLAXO GROUP LIMITED (GB) | 2004-06-09 | — | — | EP | disclosed |
| WO-2003091204-A1 | PHENETHANOLAMINE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 2003-11-06 | — | — | WO | disclosed |
| WO-2003024439-A1 | PHENETHANOLAMINE DERIVATIVES FOR TREATMENT OF RESPIRATORY DISEASES | GLAXO GROUP LIMITED (GB) | 2003-03-27 | — | — | WO | disclosed |
| EP-0377308-B1 | Phenolic resins | BORDEN UK LTD (GB) | 1993-11-03 | — | — | EP | disclosed |
| US-5051454-A | An esterified phenolic compound, an unesterified phenolic resole and a base and curing | BORDEN, INC. (US) | 1991-09-24 | — | — | US | disclosed |
| EP-0377308-A1 | Phenolic resins | BORDEN (UK) LIMITED (GB) | 1990-07-11 | — | — | EP | disclosed |
| WO-1990006904-A2 | PHENOLIC RESINS | BORDEN (UK) LIMITED (GB) | 1990-06-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090068273-A1 | Inhalation devices for delivering phenethanolamine derivatives for the treatment of respiratory diseases | PNMT, CHRM3, HRH4 | AKR1B1 2819/4885PKM 1267/4885HSPA5 522/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.