⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL324333 | 0.72 | GSK3A (0.33) | — | |
| SCHEMBL29941281 | 0.64 | — | — | |
| SCHEMBL6902949 | 0.61 | — | — | |
| SCHEMBL5619234 | 0.61 | — | — | |
| SCHEMBL19616941 | 0.53 | — | — | |
| SCHEMBL3102197 | 0.51 | — | — | |
| SCHEMBL432911 | 0.49 | — | — | |
| SCHEMBL29546936 | 0.47 | — | — | |
| SCHEMBL12276842 | 0.46 | GSK3A (0.41) | — | |
| SCHEMBL11003116 | 0.46 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0318902-A2 | Use of linear annelated tricyclics as inhibitors of erythrocyte aggregation | Roche Diagnostics GmbH (DE) | 1989-06-07 | — | — | EP | claimed |
| US-20090143375-A1 | Tricyclic Lactam Derivatives, Their Manufacture and Use as Pharmaceutical Agents | F. HOFFMANN-LA ROCHE AG (CH) | 2009-06-04 | — | — | US | disclosed |
| EP-0161632-B1 | PYRROLO-BENZIMIDAZOLES, PROCESS FOR THEIR PREPARATION, MEDICAMENTS CONTAINING THEM AND INTERMEDIATES | Roche Diagnostics GmbH (DE) | 1991-04-10 | — | — | EP | disclosed |
| EP-0186010-B1 | PYRROLO BENZIMIDAZOLES, PROCESS FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING THEM | Roche Diagnostics GmbH (DE) | 1990-01-31 | — | — | EP | disclosed |
| EP-0161632-A2 | Pyrrolo-benzimidazoles, process for their preparation, medicaments containing them and intermediates | Roche Diagnostics GmbH (DE) | 1985-11-21 | — | — | EP | disclosed |