Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 13/20 | 0.64 |
| ▸ | CDK7 | P50613 | 11/20 | 0.60 |
| ▸ | ITK | Q08881 | 7/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5054005 | 0.96 | CHEK1 (0.62) | CHEK1CDK7ITK | |
| SCHEMBL5061264 | 0.92 | ITK (0.62) | CHEK1CDK7ITK | |
| SCHEMBL5054027 | 0.89 | ITK (0.60) | CHEK1CDK7ITK | |
| SCHEMBL5051804 | 0.88 | CHEK1 (0.57) | CHEK1CDK7ITK | |
| SCHEMBL5061452 | 0.87 | ITK (0.66) | CHEK1CDK7ITK | |
| SCHEMBL5054011 | 0.86 | CHEK1 (0.57) | CHEK1CDK7ITK | |
| SCHEMBL5054272 | 0.82 | CHEK1 (0.61) | CHEK1CDK7ITK | |
| SCHEMBL5061389 | 0.82 | ITK (0.67) | CHEK1CDK7ITK | |
| SCHEMBL5051837 | 0.82 | CHEK1 (0.62) | CHEK1CDK7ITK | |
| SCHEMBL28770433 | 0.82 | CHEK1 (0.47) | CHEK1CDK7ITK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101115724-A | Inhibitors of checkpoint kinases | MERCK & CO INC (US) | 2008-01-30 | — | — | CN | claimed |
| US-20080004259-A1 | Inhibitors of Checkpoint Kinases | MERCK & CO., INC. | 2008-01-03 | — | — | US | claimed |
| EP-1851203-A2 | INHIBITORS OF CHECKPOINT KINASES | Merck & Co., Inc. (US) | 2007-11-07 | — | — | EP | claimed |
| WO-2006086255-A2 | INHIBITORS OF CHECKPOINT KINASES | MERCK & CO., INC. (US) | 2006-08-17 | — | — | WO | claimed |
| US-20090247504-A1 | Indazole Derivatives for Treatment of Alzheimer's Disease | MERCK SHARP & DOHME LIMITED (GB) | 2009-10-01 | — | — | US | disclosed |
| US-20090247504-A1 | Indazole Derivatives for Treatment of Alzheimer's Disease | MERCK SHARP & DOHME LIMITED (GB) | 2009-10-01 | — | — | US | disclosed |
| US-20090192155-A1 | Identification of Compounds Suitable for Treating Ad | MERCK SHARP & DOHME LIMITED (GB) | 2009-07-30 | — | — | US | disclosed |
| CN-101115724-A | Inhibitors of checkpoint kinases | MERCK & CO INC (US) | 2008-01-30 | — | — | CN | disclosed |
| US-20080004259-A1 | Inhibitors of Checkpoint Kinases | MERCK & CO., INC. | 2008-01-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090247504-A1 | Indazole Derivatives for Treatment of Alzheimer's Disease | MAPT, PSEN2, PSEN1 | CHEK1 1733/4885CDK7 281/4885ITK 1958/4885 |
| US-20090192155-A1 | Identification of Compounds Suitable for Treating Ad | PSEN2, MAPT, PSEN1 | CHEK1 2578/4885CDK7 413/4885ITK 4578/4885 |
| US-20080004259-A1 | Inhibitors of Checkpoint Kinases | CHEK1, CHEK2, BUB1B | CHEK1 1/4885CDK7 43/4885ITK 493/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.