SCHEMBL4152167

SCHEMBL4152167

O=C(O)CCN1CCn2c3c(c4cc(C5CCCCC5)ccc42)CCCC31

nearest known ligand 0.74

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 8/20 0.63
KMT2A Q03164 7/20 0.63
KDM4E B2RXH2 7/20 0.63
ALDH1A1 P00352 6/20 0.63
LMNA P02545 5/20 0.63
MAPK1 P28482 4/20 0.63
GAA P10253 4/20 0.63
TP53 P04637 3/20 0.63
TDP1 Q9NUW8 3/20 0.63
NPSR1 Q6W5P4 3/20 0.63
CCR6 P51684 2/20 0.63
HTT P42858 2/20 0.63
MEN1 O00255 6/20 0.55
PAX8 Q06710 1/20 0.54
CYP1A2 P05177 1/20 0.53
CYP3A4 P08684 1/20 0.53
CYP2D6 P10635 1/20 0.53
CYP2C9 P11712 1/20 0.53
CYP2C19 P33261 1/20 0.53
HSD17B10 Q99714 3/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16433502 0.90 MAPT (0.58) MAPTKMT2AKDM4EALDH1A1LMNA
SCHEMBL16724480 0.89 MAPT (0.64) MAPTKMT2AKDM4EALDH1A1LMNA
SCHEMBL17460912 0.79 KMT2A (0.69) MAPTKMT2AKDM4EALDH1A1LMNA
SCHEMBL7629176 0.77 KDM4E (1.00) MAPTKMT2AKDM4EALDH1A1LMNA
SCHEMBL15167872 0.77 MAPT (0.59) MAPTKMT2AKDM4EALDH1A1LMNA
SCHEMBL10005901 0.77 MAPT (0.73) MAPTKMT2AKDM4EALDH1A1LMNA
SCHEMBL12948593 0.75 KMT2A (0.58) MAPTKMT2AKDM4EALDH1A1LMNA
SCHEMBL12164269 0.75 KDM4E (0.71) MAPTKMT2AKDM4EALDH1A1LMNA
Benzamide SCHEMBL16418204 0.74 MAPT (0.60) MAPTKMT2AKDM4EALDH1A1LMNA
SCHEMBL12922443 0.73 KMT2A (0.68) MAPTKMT2AKDM4EALDH1A1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9271960-B2 Tetrahydrocarbazoles as active agents for inhibiting VEGF production by translational control PTC THERAPEUTICS, INC. (US) 2016-03-01 US disclosed
US-9271960-B2 Tetrahydrocarbazoles as active agents for inhibiting VEGF production by translational control PTC THERAPEUTICS, INC. (US) 2016-03-01 US disclosed
US-9271960-B2 Tetrahydrocarbazoles as active agents for inhibiting VEGF production by translational control PTC THERAPEUTICS, INC. (US) 2016-03-01 US disclosed
US-20150141418-A1 TETRAHYDROCARBAZOLES AS ACTIVE AGENTS FOR INHIBITING VEGF PRODUCTION BY TRANSLATIONAL CONTROL PTC THERAPEUTICS, INC. (US) 2015-05-21 US disclosed
US-20150141418-A1 TETRAHYDROCARBAZOLES AS ACTIVE AGENTS FOR INHIBITING VEGF PRODUCTION BY TRANSLATIONAL CONTROL PTC THERAPEUTICS, INC. (US) 2015-05-21 US disclosed
US-20150141418-A1 TETRAHYDROCARBAZOLES AS ACTIVE AGENTS FOR INHIBITING VEGF PRODUCTION BY TRANSLATIONAL CONTROL PTC THERAPEUTICS, INC. (US) 2015-05-21 US disclosed
US-8946444-B2 Tetrahydrocarbazoles as active agents for inhibiting VEGF production by translational control PTC THERAPEUTICS, INC. (US) 2015-02-03 US disclosed
US-8946444-B2 Tetrahydrocarbazoles as active agents for inhibiting VEGF production by translational control PTC THERAPEUTICS, INC. (US) 2015-02-03 US disclosed
US-8946444-B2 Tetrahydrocarbazoles as active agents for inhibiting VEGF production by translational control PTC THERAPEUTICS, INC. (US) 2015-02-03 US disclosed
US-20090042866-A1 Tetrahydrocarbazoles as Active Agents for Inhibiting VEGF Production by Translational Control PTC THERAPEUTICS, INC. 2009-02-12 US disclosed
US-20090042866-A1 Tetrahydrocarbazoles as Active Agents for Inhibiting VEGF Production by Translational Control PTC THERAPEUTICS, INC. 2009-02-12 US disclosed
US-20090042866-A1 Tetrahydrocarbazoles as Active Agents for Inhibiting VEGF Production by Translational Control PTC THERAPEUTICS, INC. 2009-02-12 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090042866-A1 Tetrahydrocarbazoles as Active Agents for Inhibiting VEGF Production by Translational Control VEGFA, FLT4, KDR MAPT 2774/4885KMT2A 3806/4885KDM4E 518/4885
US-20150141418-A1 TETRAHYDROCARBAZOLES AS ACTIVE AGENTS FOR INHIBITING VEGF PRODUCTION BY TRANSLATIONAL CONTROL VEGFA, FLT4, KDR MAPT 2774/4885KMT2A 3806/4885KDM4E 518/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.