Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 8/20 | 1.00 |
| ▸ | MAPT | P10636 | 8/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 1.00 |
| ▸ | GAA | P10253 | 4/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 4/20 | 1.00 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 1.00 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 1.00 |
| ▸ | LMNA | P02545 | 4/20 | 1.00 |
| ▸ | TP53 | P04637 | 3/20 | 1.00 |
| ▸ | CCR6 | P51684 | 2/20 | 1.00 |
| ▸ | HTT | P42858 | 2/20 | 1.00 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.77 |
| ▸ | USP2 | O75604 | 2/20 | 0.77 |
| ▸ | MEN1 | O00255 | 7/20 | 0.57 |
| ▸ | YAP1 | P46937 | 1/20 | 0.57 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.57 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12164269 | 0.83 | KDM4E (0.71) | KDM4EKMT2AMAPTALDH1A1GAA | |
| SCHEMBL17460912 | 0.82 | KMT2A (0.69) | KDM4EKMT2AMAPTALDH1A1GAA | |
| SCHEMBL17584985 | 0.79 | MAPT (0.65) | KDM4EKMT2AMAPTALDH1A1GAA | |
| SCHEMBL16724480 | 0.78 | MAPT (0.64) | KDM4EKMT2AMAPTALDH1A1GAA | |
| SCHEMBL4152167 | 0.77 | MAPT (0.63) | KDM4EKMT2AMAPTALDH1A1GAA | |
| Benzamide SCHEMBL16418204 | 0.75 | MAPT (0.60) | KDM4EKMT2AMAPTALDH1A1GAA | |
| SCHEMBL15167872 | 0.74 | MAPT (0.59) | KDM4EKMT2AMAPTALDH1A1GAA | |
| SCHEMBL4167139 | 0.74 | MAPT (0.59) | KDM4EKMT2AMAPTALDH1A1GAA | |
| SCHEMBL16433502 | 0.74 | MAPT (0.58) | KDM4EKMT2AMAPTALDH1A1GAA | |
| SCHEMBL16848296 | 0.73 | KMT2A (0.81) | KDM4EKMT2AMAPTALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6444434-B1 | COMPOUNDS INHIBITING THE ACTIVATION OF FX TO FXA BY TF/FVIIA. THE COMPOUNDS ARE ANTICOAGULANTS. THE INVENTION ALSO RELATES TO A METHOD OF IDENTIFYING A DRUG CANDIDATE. | NOVO NORDISK A/S (DK) | 2002-09-03 | — | — | US | disclosed |