SCHEMBL4152879

SCHEMBL4152879

O=C(Nc1ccccc1)c1c(Cl)cc(Cl)cc1Cl

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTPRC P08575 1/20 0.61
RAB9A P51151 3/20 0.58
MEN1 O00255 3/20 0.58
MAPT P10636 3/20 0.58
KMT2A Q03164 3/20 0.58
NPSR1 Q6W5P4 1/20 0.58
GAA P10253 1/20 0.55
TMPRSS4 Q9NRS4 1/20 0.54
F12 P00748 1/20 0.54
NPC1 O15118 3/20 0.53
JAK2 O60674 2/20 0.53
TYK2 P29597 2/20 0.53
CYP3A4 P08684 1/20 0.53
JAK1 P23458 1/20 0.53
LMNA P02545 1/20 0.51
HTT P42858 1/20 0.51
PTGS2 P35354 1/20 0.51
STK39 Q9UEW8 1/20 0.51
KCNK3 O14649 1/20 0.50
KCNK9 Q9NPC2 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11581640 0.89 TMPRSS4 (0.55) PTPRCRAB9AMEN1MAPTKMT2A
SCHEMBL4218208 0.89 FADS1 (0.51) PTPRCRAB9AMEN1MAPTKMT2A
SCHEMBL16478278 0.86 MEN1 (0.60) PTPRCRAB9AMEN1MAPTKMT2A
SCHEMBL15544101 0.86 NR1H4 (0.57) PTPRCRAB9AMEN1MAPTKMT2A
SCHEMBL4154853 0.85 TYK2 (0.71) MEN1MAPTKMT2AGAAJAK2
SCHEMBL1706582 0.82 TYK2 (0.73) MEN1KMT2AJAK2TYK2CYP3A4
SCHEMBL4929083 0.82 PTPRC (0.49) PTPRCRAB9AMEN1MAPTKMT2A
SCHEMBL21133270 0.82 MEN1 (0.59) PTPRCRAB9AMEN1MAPTKMT2A
SCHEMBL15544240 0.80 KMT2A (0.66) RAB9AMEN1MAPTKMT2AGAA
SCHEMBL7114764 0.80 GAA (0.53) RAB9AMEN1MAPTKMT2ANPSR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090131657-A1 PROCESS FOR ALKENYLATING CARBOXAMIDES BASF SE (DE) 2009-05-21 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090131657-A1 PROCESS FOR ALKENYLATING CARBOXAMIDES PRMT5, CYC1, CBR3 PTPRC 4568/4885RAB9A 3925/4885MEN1 303/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.