Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 6/20 | 0.33 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 2/20 | 0.32 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | MMP1 | P03956 | 2/20 | 0.31 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.31 |
| ▸ | KDM6B | O15054 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.30 |
| ▸ | POLB | P06746 | 2/20 | 0.30 |
| ▸ | GAA | P10253 | 2/20 | 0.30 |
| ▸ | HPGD | P15428 | 2/20 | 0.30 |
| ▸ | RECQL | P46063 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5072344 | 0.89 | NPC1 (0.45) | NPC1LMNARAB9AMAPTMEN1 | |
| SCHEMBL5135127 | 0.87 | MAPT (0.35) | NPC1LMNARAB9AMAPTSMN1; SMN2 | |
| SCHEMBL7644009 | 0.87 | NPC1 (0.33) | NPC1LMNARAB9AMEN1KMT2A | |
| SCHEMBL21693913 | 0.85 | MAPK14 (0.32) | RXFP1MAPTTP53 | |
| SCHEMBL22721242 | 0.84 | HMGCR (0.32) | MEN1KMT2AKDM4EGAA | |
| SCHEMBL25409485 | 0.83 | NPC1 (0.36) | NPC1LMNARAB9AMAPTMEN1 | |
| SCHEMBL28260891 | 0.82 | KDM6B (0.38) | NPC1LMNARAB9ARXFP1MAPT | |
| SCHEMBL29514848 | 0.81 | APP (0.38) | NPC1LMNARAB9ARXFP1MAPT | |
| SCHEMBL4196803 | 0.81 | APP (0.38) | NPC1LMNARAB9ARXFP1MAPT | |
| SCHEMBL27623464 | 0.80 | RAB9A (0.42) | NPC1LMNARAB9ARXFP1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021020512-A1 | DRUG-CONTAINING OPHTHALMIC LENS | 興和株式会社 | 2021-02-04 | — | — | WO | disclosed |
| US-20090247662-A1 | Contact Lens Material | MATSUMOTO MASAHIRO | 2009-10-01 | — | — | US | disclosed |
| EP-1178080-B1 | Curable resin coating composition | NIPPON CATALYTIC CHEM IND (JP) | 2007-04-25 | — | — | EP | disclosed |
| EP-0657751-A2 | Soft ocular lens material | Menicon Co., Ltd. (JP) | 1995-06-14 | — | — | EP | disclosed |
| EP-0600269-A2 | Soft ocular lens material | Menicon Co., Ltd. (JP) | 1994-06-08 | — | — | EP | disclosed |