⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1038352 | 0.75 | — | — | |
| SCHEMBL5270227 | 0.75 | — | — | |
| SCHEMBL15535909 | 0.71 | — | — | |
| SCHEMBL1542620 | 0.71 | — | — | |
| SCHEMBL4150325 | 0.71 | — | — | |
| SCHEMBL23478939 | 0.71 | — | — | |
| SCHEMBL7256428 | 0.71 | — | — | |
| SCHEMBL8264421 | 0.71 | — | — | |
| SCHEMBL28399850 | 0.69 | — | — | |
| SCHEMBL21026293 | 0.68 | DAO (0.52) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 60 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119585242-A | RAF kinase inhibitors and methods of use thereof | 德西费拉制药有限责任公司 | 2025-03-07 | — | — | CN | disclosed |
| EP-4444430-A1 | RAF KINASE INHIBITORS AND METHODS OF USE THEREOF | Deciphera Pharmaceuticals, LLC (US) | 2024-10-16 | — | — | EP | disclosed |
| EP-3997096-B1 | NEW HETEROCYCLIC COMPOUNDS | HOFFMANN LA ROCHE (CH) | 2024-08-28 | — | — | EP | disclosed |
| US-20230391758-A1 | MODIFIED BENZOFURAN-CARBOXAMIDES AS GLUCOSYLCERAMIDE SYNTHASE INHIBITORS | MERCK SHARP & DOHME LLC (US) | 2023-12-07 | — | — | US | disclosed |
| US-20230357179-A1 | RAF KINASE INHIBITORS AND METHODS OF USE THEREOF | DECIPHERA PHARMACEUTICALS, LLC | 2023-11-09 | — | — | US | disclosed |
| EP-4213832-A1 | MODIFIED BENZOFURAN-CARBOXAMIDES AS GLUCOSYLCERAMIDE SYNTHASE INHIBITORS | Merck Sharp & Dohme LLC (US) | 2023-07-26 | — | — | EP | disclosed |
| WO-2023108103-A1 | RAF KINASE INHIBITORS AND METHODS OF USE THEREOF | DECIPHERA PHARMACEUTICALS, LLC (US) | 2023-06-15 | — | — | WO | disclosed |
| CN-110997656-B | Substituted indole compounds useful as TLR7/8/9 inhibitors | 百时美施贵宝公司 | 2023-04-14 | — | — | CN | disclosed |
| US-11447466-B2 | Substituted indole compounds useful as inhibitors of TLR7/8/9 | BRISTOL-MYERS SQUIBB COMPANY (US) | 2022-09-20 | — | — | US | disclosed |
| US-20220242876-A1 | HETEROCYCLIC COMPOUNDS | HOFFMANN-LA ROCHE INC. (US) | 2022-08-04 | — | — | US | disclosed |
| US-6143751-A | Pyridine derivatives and pharmaceutical compositions containing them | ASTRAZENECA UK LIMITED (GB) | 2000-11-07 | — | — | US | disclosed |
| EP-0984961-A1 | NOVEL PYRIDINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Astra Pharmaceuticals Limited (GB) | 2000-03-15 | — | — | EP | disclosed |
| WO-1998043971-A1 | NOVEL PYRIDINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | ASTRA PHARMACEUTICALS LTD. (GB) | 1998-10-08 | — | — | WO | disclosed |
| US-5677458-A | Method of preparing azatetralones | PFIZER INC. (US) | 1997-10-14 | — | — | US | disclosed |
| US-5608071-A | Synthesis of 3-bromo-5-chloro-2-alkyl-pyridine derivatives | PFIZER INC. (US) | 1997-03-04 | — | — | US | disclosed |
| US-5436344-A | 3-bromo-5-chloro-pyridines used as intermediates in the synthesis of azatetralones | PFIZER INC. (US) | 1995-07-25 | — | — | US | disclosed |
| US-5336771-A | Certain 3,4-dihydro-2H-pyrano[2,3-b]pyridines | PFIZER INC. (US) | 1994-08-09 | — | — | US | disclosed |
| EP-0445950-B1 | Novel pyridine derivatives and processes for their synthesis | PFIZER (US) | 1994-06-08 | — | — | EP | disclosed |
| US-5068333-A | 6-chloro-3,4-dihydro-pyrano [2,3-b]pyridines having the R configuration | PFIZER INC. (US) | 1991-11-26 | — | — | US | disclosed |
| EP-0445950-A1 | Novel pyridine derivatives and processes for their synthesis | PFIZER INC. (US) | 1991-09-11 | — | — | EP | disclosed |