⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4257130 | 0.75 | — | — | |
| SCHEMBL1542620 | 0.75 | — | — | |
| SCHEMBL620683 | 0.75 | — | — | |
| SCHEMBL1853196 | 0.75 | — | — | |
| SCHEMBL590523 | 0.75 | — | — | |
| SCHEMBL4154284 | 0.75 | — | — | |
| SCHEMBL1887803 | 0.75 | — | — | |
| SCHEMBL17546137 | 0.72 | ERCC1 (0.52) | — | |
| SCHEMBL2704343 | 0.70 | NOTUM (0.52) | — | |
| SCHEMBL3069301 | 0.70 | MCL1 (0.58) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 100 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4574828-A2 | PROCESS FOR PREPARING BTK INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2025-06-25 | — | — | EP | disclosed |
| US-20240425481-A1 | SUBSTITUTED BENZIMIDAZOLES, THEIR PREPARATION AND THEIR USE AS PHARMACEUTICALS | EPIGENETIX, INC. | 2024-12-26 | — | — | US | disclosed |
| US-11981657-B2 | Substituted benzimidazoles, their preparation and their use as pharmaceuticals | EPIGENETIX, INC. (US) | 2024-05-14 | — | — | US | disclosed |
| US-20230357179-A1 | RAF KINASE INHIBITORS AND METHODS OF USE THEREOF | DECIPHERA PHARMACEUTICALS, LLC | 2023-11-09 | — | — | US | disclosed |
| US-20230348471-A1 | BRUTON'S TYROSINE KINASE INHIBITOR AND PREPARATION METHOD THEREFOR | ZHEJIANG HUAHAI PHARMACEUTICAL CO., LTD. (CN) | 2023-11-02 | — | — | US | disclosed |
| US-20230348471-A1 | BRUTON'S TYROSINE KINASE INHIBITOR AND PREPARATION METHOD THEREFOR | ZHEJIANG HUAHAI PHARMACEUTICAL CO., LTD. (CN) | 2023-11-02 | — | — | US | disclosed |
| US-20230250103-A1 | PROCESS FOR PREPARING BTK INHIBITORS | GENENTECH, INC. (US) | 2023-08-10 | — | — | US | disclosed |
| US-20230250103-A1 | PROCESS FOR PREPARING BTK INHIBITORS | GENENTECH, INC. (US) | 2023-08-10 | — | — | US | disclosed |
| US-20230250103-A1 | PROCESS FOR PREPARING BTK INHIBITORS | GENENTECH, INC. (US) | 2023-08-10 | — | — | US | disclosed |
| US-11661424-B2 | Process for preparing BTK inhibitors | GENENTECH, INC. (US) | 2023-05-30 | — | — | US | disclosed |
| WO-2008033858-A2 | KINASE INHIBITORS, AND METHODS OF USING AND IDENTIFYING KINASE INHIBITORS | CGI PHARMACEUTICALS, INC. (US) | 2008-03-20 | — | — | WO | disclosed |
| WO-2008033854-A1 | CERTAIN SUBSTITUTED AMIDES, METHOD OF MAKING, AND METHOD OF USE THEREOF | CGI PHARMACEUTICALS, INC. (US) | 2008-03-20 | — | — | WO | disclosed |
| WO-2008033857-A2 | SUBSTITUTED AMIDES, METHOD OF MAKING, AND METHOD OF USE THEREOF | CGI PHARMACEUTICALS, INC. (US) | 2008-03-20 | — | — | WO | disclosed |
| EP-1863766-A2 | CERTAIN SUBSTITUTED AMIDES, METHOD OF MAKING, AND METHOD OF USE THEREOF | CGI Pharmaceuticals, Inc. (US) | 2007-12-12 | — | — | EP | disclosed |
| US-20060229337-A1 | Certain substituted amides, method of making, and method of use thereof | GILEAD CONNECTICUT, INC. | 2006-10-12 | — | — | US | disclosed |
| WO-2006099075-A2 | CERTAIN SUBSTITUTED AMIDES, METHOD OF MAKING, AND METHOD OF USE THEREOF | CGI PHARMACEUTICALS, INC. (US) | 2006-09-21 | — | — | WO | disclosed |
| US-20040186104-A1 | Novel pyridinone and related heterocyclic derivatives | ASTRAZENECA AB (SE) | 2004-09-23 | — | — | US | disclosed |
| EP-1387829-A1 | NOVEL PYRIDINONE AND RELATED HETEROCYCLIC DERIVATIVES | AstraZeneca AB (SE) | 2004-02-11 | — | — | EP | disclosed |
| WO-2002090333-A1 | NOVEL PYRIDINONE AND RELATED HETEROCYCLIC DERIVATIVES | ASTRAZENECA AB (SE) | 2002-11-14 | — | — | WO | disclosed |
| US-4008086-A | PYRIDONE OR PYRIDAZONE DERIVATIVES | KONISHIROKU PHOTO INDUSTRY CO., LTD. (JA) | 1977-02-15 | — | — | US | disclosed |