Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNC | P24863 | 16/20 | 0.52 |
| ▸ | CDK8 | P49336 | 16/20 | 0.52 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.46 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.46 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.40 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.40 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.40 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3669196 | 0.92 | MAP3K11 (0.46) | CCNCCDK8TGFBR1TGFBR2MAP3K11 | |
| SCHEMBL4159014 | 0.85 | PLK4 (0.44) | TGFBR1TGFBR2 | |
| SCHEMBL3729500 | 0.81 | TGFBR1 (0.48) | CDK8TGFBR1TGFBR2 | |
| SCHEMBL3724172 | 0.80 | TGFBR1 (0.56) | TGFBR1TGFBR2 | |
| SCHEMBL4150736 | 0.80 | TGFBR1 (0.42) | TGFBR1TGFBR2 | |
| SCHEMBL4155524 | 0.80 | MAP3K11 (0.47) | CCNCCDK8TGFBR1TGFBR2MAP3K11 | |
| SCHEMBL4152923 | 0.80 | TGFBR1 (0.53) | TGFBR1TGFBR2 | |
| SCHEMBL4158011 | 0.80 | TGFBR1 (0.44) | CDK8MKNK1MKNK2TGFBR1TGFBR2 | |
| SCHEMBL3666832 | 0.80 | TGFBR1 (0.44) | CDK8TGFBR1TGFBR2 | |
| SCHEMBL4161342 | 0.79 | TTK (0.46) | PTK2TGFBR1TGFBR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8314112-B2 | Pyrrolopyrimidines and pyrrolopyridines | NOVARTIS AG (CH) | 2012-11-20 | — | — | US | claimed |
| US-8314112-B2 | Pyrrolopyrimidines and pyrrolopyridines | NOVARTIS AG (CH) | 2012-11-20 | — | — | US | disclosed |
| US-20090181941-A1 | Pyrrolopyrimidines and Pyrrolopyridines | NOVARTIS AG (CH) | 2009-07-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090181941-A1 | Pyrrolopyrimidines and Pyrrolopyridines | ALK, ACVR1, PTPN4 | CCNC 2517/4885CDK8 844/4885MKNK1 3357/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.