Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2A6 | P11509 | 2/20 | 0.49 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.46 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.46 |
| ▸ | CDK1 | P06493 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | AKT1 | P31749 | 1/20 | 0.39 |
| ▸ | AKT2 | P31751 | 1/20 | 0.39 |
| ▸ | PGR | P06401 | 1/20 | 0.39 |
| ▸ | KIF11 | P52732 | 2/20 | 0.39 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.36 |
| ▸ | PDE2A | O00408 | 1/20 | 0.35 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.35 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5160 | 0.82 | CYP11B1 (0.61) | CYP2A6CYP11B2CYP11B1KIF11PTGS2 | |
| SCHEMBL13778375 | 0.81 | CYP2A6 (0.50) | CYP2A6CYP11B2CYP11B1AKT1AKT2 | |
| SCHEMBL3664772 | 0.80 | CYP11B2 (0.44) | CYP2A6CYP11B2CYP11B1PGRKIF11 | |
| SCHEMBL5116017 | 0.76 | CYP2A6 (0.52) | CYP2A6CYP11B2CYP11B1PGRPTK2 | |
| SCHEMBL3374955 | 0.76 | CYP2A6 (0.52) | CYP2A6CYP11B2CYP11B1PGRPTK2 | |
| SCHEMBL5110764 | 0.76 | CYP2A6 (0.52) | CYP2A6CYP11B2CYP11B1PGRPTK2 | |
| SCHEMBL31303064 | 0.76 | CYP11B2 (0.50) | CYP11B2CYP11B1KIF11MAP4K4 | |
| SCHEMBL17164814 | 0.74 | PDE2A (0.54) | AKT1AKT2KIF11PDE2ASCN10A | |
| SCHEMBL14392676 | 0.74 | CYP2A6 (0.61) | CYP2A6CYP11B2CYP11B1PGRPTK2 | |
| SCHEMBL3668760 | 0.73 | CYP11B1 (0.39) | CYP2A6CYP11B2CYP11B1PGRKIF11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8314112-B2 | Pyrrolopyrimidines and pyrrolopyridines | NOVARTIS AG (CH) | 2012-11-20 | — | — | US | disclosed |
| CN-101970435-A | Pyrrolopyrimidines and pyrrolopyridines | NOVARTIS AG | 2011-02-09 | — | — | CN | disclosed |
| US-20090181941-A1 | Pyrrolopyrimidines and Pyrrolopyridines | NOVARTIS AG (CH) | 2009-07-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090181941-A1 | Pyrrolopyrimidines and Pyrrolopyridines | ALK, ACVR1, PTPN4 | CYP2A6 1045/4885CYP11B2 1994/4885CYP11B1 1713/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.