Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FABP3 | P05413 | 1/20 | 0.79 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.65 |
| ▸ | NR5A2 | O00482 | 1/20 | 0.65 |
| ▸ | NR5A1 | Q13285 | 1/20 | 0.65 |
| ▸ | PRKCA | P17252 | 4/20 | 0.61 |
| ▸ | PRKCE | Q02156 | 2/20 | 0.61 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.61 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.61 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | LPAR3 | Q9UBY5 | 7/20 | 0.56 |
| ▸ | LPAR1 | Q92633 | 4/20 | 0.56 |
| ▸ | ENPP2 | Q13822 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | LPAR2 | Q9HBW0 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL776856 | 0.93 | FABP3 (0.72) | FABP3SMN1; SMN2NR5A2NR5A1PRKCA | |
| Phosphocholine SCHEMBL26629479 | 0.89 | FABP3 (0.74) | FABP3SMN1; SMN2NR5A2NR5A1PRKCA | |
| Phosphocholine SCHEMBL16102973 | 0.89 | FABP3 (0.74) | FABP3SMN1; SMN2NR5A2NR5A1PRKCA | |
| Phosphocholine SCHEMBL480378 | 0.89 | FABP3 (0.74) | FABP3SMN1; SMN2NR5A2NR5A1PRKCA | |
| 1,2-Dipalmitin SCHEMBL1833548 | 0.89 | FABP3 (0.74) | FABP3SMN1; SMN2NR5A2NR5A1PRKCA | |
| SCHEMBL31400386 | 0.89 | FABP3 (0.81) | FABP3SMN1; SMN2NR5A2NR5A1PRKCA | |
| SCHEMBL31106468 | 0.89 | FABP3 (0.81) | FABP3SMN1; SMN2NR5A2NR5A1PRKCA | |
| SCHEMBL31362195 | 0.89 | FABP3 (0.81) | FABP3SMN1; SMN2NR5A2NR5A1PRKCA | |
| SCHEMBL21680883 | 0.89 | FABP3 (0.81) | FABP3SMN1; SMN2NR5A2NR5A1PRKCA | |
| SCHEMBL31425003 | 0.89 | FABP3 (0.81) | FABP3SMN1; SMN2NR5A2NR5A1PRKCA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2595602-B1 | SUSTAINED RELEASE siRNA FOR OCULAR DRUG DELIVERY | ALLERGAN INC (US) | 2018-05-23 | — | — | EP | claimed |
| US-20120022002-A1 | SUSTAINED RELEASE siRNA FOR OCULAR DRUG DELIVERY | ALLERGAN, INC. | 2012-01-26 | — | — | US | claimed |
| EP-2595602-B1 | SUSTAINED RELEASE siRNA FOR OCULAR DRUG DELIVERY | ALLERGAN INC (US) | 2018-05-23 | — | — | EP | disclosed |
| US-9480646-B2 | Sustained release siRNA for ocular drug delivery | ALLERGAN, INC. (US) | 2016-11-01 | — | — | US | disclosed |
| US-20150141348-A1 | SUSTAINED RELEASE siRNA FOR OCULAR DRUG DELIVERY | ALLERGAN, INC. | 2015-05-21 | — | — | US | disclosed |
| US-8946170-B2 | Sustained release siRNA for ocular drug delivery | ALLERGAN, INC. (US) | 2015-02-03 | — | — | US | disclosed |
| US-20120022002-A1 | SUSTAINED RELEASE siRNA FOR OCULAR DRUG DELIVERY | ALLERGAN, INC. | 2012-01-26 | — | — | US | disclosed |