Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.48 |
| ▸ | MAPT | P10636 | 5/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | CDK5 | Q00535 | 7/20 | 0.47 |
| ▸ | CDK5R1 | Q15078 | 7/20 | 0.47 |
| ▸ | CDC25A | P30304 | 2/20 | 0.44 |
| ▸ | CDC25B | P30305 | 2/20 | 0.44 |
| ▸ | CDC25C | P30307 | 2/20 | 0.44 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Propionic Acid SCHEMBL4155444 | 0.87 | PARP1 (0.43) | SMN1; SMN2MAPTALDH1A1MEN1KMT2A | |
| Propionic Acid SCHEMBL4153298 | 0.87 | PARP1 (0.45) | SMN1; SMN2MAPTALDH1A1MEN1KMT2A | |
| Propionic Acid SCHEMBL4153840 | 0.85 | PIM1 (0.44) | MAPTALDH1A1MEN1KMT2AKDM4E | |
| Propionic Acid SCHEMBL4164428 | 0.85 | CSNK2A1 (0.48) | SMN1; SMN2MAPTALDH1A1MEN1KMT2A | |
| Propionic Acid SCHEMBL4160653 | 0.84 | CSNK2A1 (0.39) | SMN1; SMN2MAPTALDH1A1MEN1KMT2A | |
| Propionic Acid SCHEMBL4159319 | 0.84 | HDAC3 (0.48) | MAPTALDH1A1MEN1KMT2ALMNA | |
| Propionic Acid SCHEMBL4153894 | 0.82 | ALDH1A1 (0.45) | SMN1; SMN2MAPTALDH1A1MEN1KMT2A | |
| Propionic Acid SCHEMBL4158054 | 0.82 | CFTR (0.39) | SMN1; SMN2MAPTMEN1KMT2AMAPK1 | |
| Propionic Acid SCHEMBL4157999 | 0.81 | ABL1 (0.52) | SMN1; SMN2MAPTALDH1A1MEN1KMT2A | |
| Propionic Acid SCHEMBL4163705 | 0.80 | BAZ2A (0.42) | SMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8426437-B2 | Pyrroloquinoline derivatives and their use as protein kinases inhibitors | PIERRE FABRE MEDICAMENT (FR) | 2013-04-23 | — | — | US | claimed |
| US-20090042876-A1 | Pyrroloquinoline Derivatives And Their Use As Protein Kinases Inhibitors | PIERRE FABRE MEDICAMENT (FR) | 2009-02-12 | — | — | US | claimed |
| US-8426437-B2 | Pyrroloquinoline derivatives and their use as protein kinases inhibitors | PIERRE FABRE MEDICAMENT (FR) | 2013-04-23 | — | — | US | disclosed |
| US-20090042876-A1 | Pyrroloquinoline Derivatives And Their Use As Protein Kinases Inhibitors | PIERRE FABRE MEDICAMENT (FR) | 2009-02-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090042876-A1 | Pyrroloquinoline Derivatives And Their Use As Protein Kinases Inhibitors | MAP3K1, MAP3K2, MAP3K7 | SMN1; SMN2 2559/4885MAPT 734/4885ALDH1A1 3830/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.