Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 6/20 | 0.47 |
| ▸ | NOX4 | Q9NPH5 | 2/20 | 0.39 |
| ▸ | NPY2R | P49146 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | GFER | P55789 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 2/20 | 0.35 |
| ▸ | NMT1 | P30419 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | HTR2B | P41595 | 1/20 | 0.34 |
| ▸ | SYK | P43405 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27756986 | 0.84 | GRM5 (0.50) | GRM5NOX4NPY2RALDH1A1ALOX15 | |
| SCHEMBL4609669 | 0.84 | GRM5 (0.56) | GRM5NPY2RSLC6A2SLC6A3SLC6A4 | |
| SCHEMBL4608859 | 0.81 | GRM5 (0.48) | GRM5SLC6A2SLC6A3SLC6A4HTR2C | |
| SCHEMBL4611088 | 0.80 | SMN1; SMN2 (0.43) | GRM5ALDH1A1NPSR1GFERKDM4E | |
| SCHEMBL4608995 | 0.79 | GRM5 (0.45) | GRM5ALDH1A1HSD17B10KDM4ESLC6A2 | |
| SCHEMBL27756982 | 0.78 | GRM5 (0.55) | GRM5NOX4NPY2RALDH1A1ALOX15 | |
| SCHEMBL4610011 | 0.78 | SLC6A2 (0.47) | GRM5KDM4ESLC6A2SLC6A3SLC6A4 | |
| SCHEMBL4608127 | 0.77 | GRM5 (0.41) | GRM5NPY2RALDH1A1LMNASLC6A2 | |
| SCHEMBL4609680 | 0.77 | GRM5 (0.59) | GRM5SLC6A2SLC6A3SLC6A4 | |
| SCHEMBL4609000 | 0.76 | SLC6A2 (0.43) | GRM5NPY2RSLC6A2SLC6A3SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090023711-A1 | Piperazines and Piperidines as Mglur5 Potentiators | ASTRAZENECA AB (SE) | 2009-01-22 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090023711-A1 | Piperazines and Piperidines as Mglur5 Potentiators | GRM5, GRM1, GRIN1 | GRM5 1/4885NOX4 3253/4885NPY2R 217/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.