Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 7/20 | 0.56 |
| ▸ | MC4R | P32245 | 3/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | GALR3 | O60755 | 1/20 | 0.36 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
| ▸ | NPY2R | P49146 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1902514 | 0.90 | GRM5 (0.55) | GRM5SLC6A2SLC6A3TDP1MAPK1 | |
| SCHEMBL4609000 | 0.86 | SLC6A2 (0.43) | GRM5MC4RSLC6A2SLC6A3SLC6A4 | |
| SCHEMBL4608127 | 0.85 | GRM5 (0.41) | GRM5SLC6A2SLC6A3SLC6A4TP53 | |
| SCHEMBL4155422 | 0.84 | GRM5 (0.47) | GRM5SLC6A2SLC6A3SLC6A4NPY2R | |
| SCHEMBL27757098 | 0.83 | GRM5 (0.60) | GRM5MC4RTDP1NPC1MAPK1 | |
| SCHEMBL4713865 | 0.82 | GRM5 (0.52) | GRM5SLC6A2SLC6A3SLC6A4TP53 | |
| SCHEMBL4608428 | 0.82 | SLC6A2 (0.46) | GRM5MC4RSLC6A2SLC6A3SLC6A4 | |
| SCHEMBL4610011 | 0.81 | SLC6A2 (0.47) | GRM5MC4RSLC6A2SLC6A3SLC6A4 | |
| SCHEMBL4608995 | 0.79 | GRM5 (0.45) | GRM5SLC6A2SLC6A3SLC6A4P2RX7 | |
| SCHEMBL4608859 | 0.79 | GRM5 (0.48) | GRM5MC4RSLC6A2SLC6A3SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1979320-A2 | PIPERAZINES AND PIPERIDINES AS mGluR5 POTENTIATORS | AstraZeneca AB (SE) | 2008-10-15 | — | — | EP | claimed |
| WO-2007087135-A2 | PIPERAZINES AND PIPERIDINES AS mGluR5 POTENTIATORS | ASTRAZENECA AB (SE) | 2007-08-02 | — | — | WO | claimed |