Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRK6 | P43250 | 12/20 | 0.48 |
| ▸ | AURKA | O14965 | 5/20 | 0.48 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.46 |
| ▸ | HTR7 | P34969 | 7/20 | 0.39 |
| ▸ | HTR2C | P28335 | 3/20 | 0.38 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.38 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.38 |
| ▸ | HTR6 | P50406 | 2/20 | 0.38 |
| ▸ | IGF1R | P08069 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4068246 | 0.84 | NTRK1 (0.50) | GRK6AURKANTRK1IGF1R | |
| SCHEMBL4064986 | 0.79 | NTRK1 (0.53) | GRK6AURKANTRK1HTR7HTR2C | |
| SCHEMBL4073775 | 0.75 | NTRK1 (0.47) | NTRK1IGF1R | |
| SCHEMBL3341203 | 0.73 | NTRK1 (0.51) | GRK6AURKANTRK1HTR7HTR2C | |
| SCHEMBL4075878 | 0.72 | NTRK1 (0.49) | GRK6AURKANTRK1 | |
| SCHEMBL22535761 | 0.71 | NTRK1 (0.63) | GRK6AURKANTRK1HTR7HTR2C | |
| SCHEMBL2241284 | 0.70 | NTRK1 (0.43) | GRK6AURKANTRK1 | |
| SCHEMBL4147398 | 0.69 | NTRK1 (0.52) | GRK6AURKANTRK1IGF1R | |
| SCHEMBL4158277 | 0.69 | NTRK1 (0.51) | GRK6AURKANTRK1 | |
| SCHEMBL3339301 | 0.69 | NTRK1 (0.56) | NTRK1IGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090005396-A1 | Use of Pyrazolyl-Pyrimidine Derivatives in the Treatment of Pain | ASTRAZENECA AB (SE) | 2009-01-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090005396-A1 | Use of Pyrazolyl-Pyrimidine Derivatives in the Treatment of Pain | P2RX3, DPYD, TYMP | GRK6 3552/4885AURKA 2423/4885NTRK1 3656/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.