Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 2/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | HRH1 | P35367 | 1/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | CES2 | O00748 | 1/20 | 0.39 |
| ▸ | CES1 | P23141 | 1/20 | 0.39 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL522925 | 1.00 | NPC1 (0.48) | NPC1RAB9AKMT2ACACNA2D1CYP3A4 | |
| SCHEMBL1200623 | 1.00 | NPC1 (0.48) | NPC1RAB9AKMT2ACACNA2D1CYP3A4 | |
| SCHEMBL4621336 | 0.98 | NPC1 (0.47) | NPC1RAB9AKMT2ACACNA2D1CYP3A4 | |
| Hydrochloric Acid SCHEMBL27710967 | 0.98 | NPC1 (0.47) | NPC1RAB9AKMT2ACACNA2D1CYP3A4 | |
| SCHEMBL4619913 | 0.98 | NPC1 (0.47) | NPC1RAB9AKMT2ACACNA2D1CYP3A4 | |
| Hydrochloric Acid SCHEMBL27899374 | 0.98 | NPC1 (0.47) | NPC1RAB9AKMT2ACACNA2D1CYP3A4 | |
| SCHEMBL4621986 | 0.98 | NPC1 (0.47) | NPC1RAB9AKMT2ACACNA2D1CYP3A4 | |
| Alcohol SCHEMBL6236373 | 0.95 | CACNA2D1 (0.48) | NPC1RAB9AKMT2ACACNA2D1CYP3A4 | |
| Tetrahydrothiophene SCHEMBL12971275 | 0.89 | NPC1 (0.41) | NPC1RAB9AKMT2ACACNA2D1CYP3A4 | |
| SCHEMBL28016938 | 0.89 | CACNA2D1 (0.42) | NPC1RAB9AKMT2ACACNA2D1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 462 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119912460-A | Porphyrin derivatives, process for their preparation and their use for bacteriostasis | 上海光声制药有限公司 | 2025-05-02 | — | — | CN | claimed |
| CN-114163415-B | Preparation method of duloxetine hydrochloride intermediate | 珠海润都制药股份有限公司 | 2023-03-03 | — | — | CN | claimed |
| CN-115286613-B | Preparation method of duloxetine hydrochloride | 潍坊市海欣药业有限公司 | 2023-01-31 | — | — | CN | claimed |
| CN-115286613-A | Preparation method of duloxetine hydrochloride | 潍坊市海欣药业有限公司 | 2022-11-04 | — | — | CN | claimed |
| CN-114437022-A | Preparation method of duloxetine intermediate | 浙江拓普药业股份有限公司 | 2022-05-06 | — | — | CN | claimed |
| CN-114163415-A | Preparation method of duloxetine hydrochloride intermediate | 珠海润都制药股份有限公司 | 2022-03-11 | — | — | CN | claimed |
| CN-109769856-B | Diatomite insecticide, preparation method and application thereof | 广州弘源优农科技有限公司 | 2021-09-10 | — | — | CN | claimed |
| CN-112126663-A | Production process of duloxetine | 浙江拓普药业股份有限公司 | 2020-12-25 | — | — | CN | claimed |
| CN-106011096-B | Engineered ketoreductase polypeptide and method for preparing (S) -3- (dimethylamino) -1- (thiophene-2-yl) -1-propanol by using same | 苏州汉酶生物技术有限公司 | 2020-11-03 | — | — | CN | claimed |
| CN-109769856-A | Diatomaceous earth, preparation method and application | 广州弘源优农科技有限公司 | 2019-05-21 | — | — | CN | claimed |
| WO-2007045405-A1 | PROCESS FOR THE PREPARATION OF DULOXETINE | SOLMAG S.P.A. (IT) | 2007-04-26 | — | — | WO | claimed |
| CN-1304360-C | Preparation method of N,N-dimethyl-3-hydroxy-3-aryl propyl amine | UNIV TIANJIN (CN) | 2007-03-14 | — | — | CN | claimed |
| CN-1896071-A | Preparation of (S-(+)-N,N-methyl-3-(1-naphthyl-oxy)-3-(2-thienyl) propylamine | AILISI MEDICAL SCIENCE AND TEC (CN) | 2007-01-17 | — | — | CN | claimed |
| WO-2006126213-A1 | AN IMPROVED PROCESS FOR THE PREPARATION OF DULOXETINE | MATRIX LABORATORIES LTD (IN) | 2006-11-30 | — | — | WO | claimed |
| CN-1497048-A | Method for preparing 3-heteroarylradical-3-hydroxy-propionic acid derivative | 拜尔公司 | 2004-05-19 | — | — | CN | claimed |
| US-6541668-B1 | Using nucleophilic aromatic displacement in 1,3-dimethyl-2-imidazolidinone or N-methylpyrrolidinone | ELI LILLY AND COMPANY | 2003-04-01 | — | — | US | claimed |
| EP-0650965-B1 | Asymmetric synthesis of (S)-(+)-N,N-dimethyl-3-(1-naphthalenyloxy)-3-(2-thienyl)propanamine an intermediate in the preparation of duloxetine | LILLY CO ELI (US) | 2001-02-07 | — | — | EP | claimed |
| EP-0650965-A1 | Asymmetric synthesis of (S)-(+)-N,N-dimethyl-3-(1-naphthalenyloxy)-3-(2-thienyl)propanamine an intermediate in the preparation of duloxetine | ELI LILLY AND COMPANY (US) | 1995-05-03 | — | — | EP | claimed |
| US-5362886-A | Asymmetric synthesis | ELI LILLY AND COMPANY (US) | 1994-11-08 | — | — | US | claimed |
| EP-0457559-A2 | Chiral synthesis of 1-aryl-3-aminopropan-1-ols | ELI LILLY AND COMPANY (US) | 1991-11-21 | — | — | EP | claimed |