Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 2/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | HRH1 | P35367 | 1/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | CES2 | O00748 | 1/20 | 0.39 |
| ▸ | CES1 | P23141 | 1/20 | 0.39 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL522925 | 1.00 | NPC1 (0.48) | NPC1RAB9AKMT2ACACNA2D1CYP3A4 | |
| SCHEMBL4156 | 1.00 | NPC1 (0.48) | NPC1RAB9AKMT2ACACNA2D1CYP3A4 | |
| SCHEMBL4621336 | 0.98 | NPC1 (0.47) | NPC1RAB9AKMT2ACACNA2D1CYP3A4 | |
| Hydrochloric Acid SCHEMBL27710967 | 0.98 | NPC1 (0.47) | NPC1RAB9AKMT2ACACNA2D1CYP3A4 | |
| SCHEMBL4619913 | 0.98 | NPC1 (0.47) | NPC1RAB9AKMT2ACACNA2D1CYP3A4 | |
| Hydrochloric Acid SCHEMBL27899374 | 0.98 | NPC1 (0.47) | NPC1RAB9AKMT2ACACNA2D1CYP3A4 | |
| SCHEMBL4621986 | 0.98 | NPC1 (0.47) | NPC1RAB9AKMT2ACACNA2D1CYP3A4 | |
| Alcohol SCHEMBL6236373 | 0.95 | CACNA2D1 (0.48) | NPC1RAB9AKMT2ACACNA2D1CYP3A4 | |
| Tetrahydrothiophene SCHEMBL12971275 | 0.89 | NPC1 (0.41) | NPC1RAB9AKMT2ACACNA2D1CYP3A4 | |
| SCHEMBL28016938 | 0.89 | CACNA2D1 (0.42) | NPC1RAB9AKMT2ACACNA2D1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 70 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114437022-A | Preparation method of duloxetine intermediate | 浙江拓普药业股份有限公司 | 2022-05-06 | — | — | CN | claimed |
| CN-110736711-A | Detection method for preparation process of R- (+) -3- (dimethylamino) -1- (2-thienyl) -1-propanol | 南京趣酶生物科技有限公司 | 2020-01-31 | — | — | CN | claimed |
| EP-1405917-B1 | Process for the production of 3-Heteroaryl-3-hydroxy-propionic acid derivatives by enantioselective microbial reduction | SALTIGO GMBH (DE) | 2013-08-14 | — | — | EP | claimed |
| CN-102285961-B | Method for preparing chiral intermediate of duloxetine | YANGTZE RIVER PHARM GROUP CO | 2013-05-15 | — | — | CN | claimed |
| EP-2132192-B1 | NOVEL PROCESS FOR PREPARATION OF DULOXETINE HYDROCHLORIDE | LUPIN LTD (IN) | 2013-04-24 | — | — | EP | claimed |
| CN-102285961-A | Method for preparing chiral intermediate of duloxetine | — | 2011-12-21 | — | — | CN | claimed |
| WO-2011033366-A8 | IMPROVED PROCESS FOR THE PREPARATION OF DULOXETINE AND ITS PHARMACEUTICALLY ACCEPTABLE SALT | JUBILANT LIFE SCIENCES LIMITED (IN) | 2011-05-05 | — | — | WO | claimed |
| WO-2011033366-A2 | PROCESS FOR THE PREPARATION OF DULOXETINE HYDROCHLORIDE AND ITS PRECURSORS | JUBILANT LIFE SCIENCES LIMITED (IN) | 2011-03-24 | — | — | WO | claimed |
| US-7553970-B2 | Process for preparing 3-heteroaryl-3-hydroxypropanoic acid derivatives | LANXESS DEUTSCHLAND GMBH (DE) | 2009-06-30 | — | — | US | claimed |
| EP-1758879-B1 | METHOD OF MANUFACTURING (S)-N-METHYL-3-(1-NAPHTHYLOXY)-3-(2-THIENYL)PROPYLAMINE HYDROCHLORIDE (DULOXETINE) | ZENTIVA AS (CZ) | 2007-12-12 | — | — | EP | claimed |
| US-20040181058-A1 | Process for preparing 3-heteroaryl-3-hydroxypropanoic acid derivatives | LANXESS DEUTSCHLAND GMBH (DE) | 2004-09-16 | — | — | US | claimed |
| CN-1497048-A | Method for preparing 3-heteroarylradical-3-hydroxy-propionic acid derivative | 拜尔公司 | 2004-05-19 | — | — | CN | claimed |
| EP-1405917-A2 | Process for the production of 3-Heteroaryl-3-hydroxy-propionic acid derivatives by enantioselective microbial reduction | Bayer Chemicals AG (DE) | 2004-04-07 | — | — | EP | claimed |
| CN-119955874-A | Duloxetine Process for the preparation of intermediates | 南京红杉生物科技有限公司 | 2025-05-09 | — | — | CN | disclosed |
| CN-113072486-B | Amino alcohol-boron-binaphthol complex and preparation method of optically active amino alcohol derivative using same | 分子与物质株式会社 | 2024-10-11 | — | — | CN | disclosed |
| CN-117769547-A | Preparation method of 3-aryloxy-3-five-membered heteroaryl-propylamine compound | 上海璃道医药科技有限公司 | 2024-03-26 | — | — | CN | disclosed |
| EP-1405917-A2 | Process for the production of 3-Heteroaryl-3-hydroxy-propionic acid derivatives by enantioselective microbial reduction | Bayer Chemicals AG (DE) | 2004-04-07 | — | — | EP | disclosed |
| US-20030225153-A1 | Process for preparing arylaminopropanols | LANXESS DEUTSCHLAND GMBH (DE) | 2003-12-04 | — | — | US | disclosed |
| EP-1346977-A1 | Method for producing aryl-aminopropanols | Bayer Aktiengesellschaft (DE) | 2003-09-24 | — | — | EP | disclosed |
| US-6541668-B1 | Using nucleophilic aromatic displacement in 1,3-dimethyl-2-imidazolidinone or N-methylpyrrolidinone | ELI LILLY AND COMPANY | 2003-04-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030225153-A1 | Process for preparing arylaminopropanols | AHR, CYP1A1, CYP1A2 | NPC1 2343/4885RAB9A 3297/4885KMT2A 746/4885 |
| US-20040181058-A1 | Process for preparing 3-heteroaryl-3-hydroxypropanoic acid derivatives | HPD, HAAO, GRHPR | NPC1 1532/4885RAB9A 3383/4885KMT2A 1997/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.