Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | SRC | P12931 | 3/20 | 0.42 |
| ▸ | FLT3 | P36888 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 3/20 | 0.41 |
| ▸ | AVPR1B | P47901 | 5/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 4/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
| ▸ | FLT1 | P17948 | 1/20 | 0.39 |
| ▸ | FLT4 | P35916 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4156430 | 0.75 | EGFR (0.61) | SRCKDREGFRFGFR1FLT1 | |
| SCHEMBL5040071 | 0.74 | EGFR (0.61) | SRCFLT3KDREGFRFLT1 | |
| SCHEMBL15732881 | 0.67 | KMT2A (0.82) | TSHRNPSR1FLT3MEN1KMT2A | |
| SCHEMBL5423360 | 0.66 | EGFR (0.66) | SRCFLT3KDREGFRFLT1 | |
| SCHEMBL16245396 | 0.66 | HRH3 (0.54) | ALDH1A1TSHRSMN1; SMN2NPSR1SRC | |
| SCHEMBL3351728 | 0.65 | ALDH1A1 (0.51) | ALDH1A1TSHRSMN1; SMN2NPSR1SRC | |
| SCHEMBL31061228 | 0.65 | ALDH1A1 (0.51) | ALDH1A1TSHRSMN1; SMN2NPSR1SRC | |
| SCHEMBL30017995 | 0.65 | MAP2K1 (0.52) | ALDH1A1SRCKDREGFRKDM4E | |
| SCHEMBL23804879 | 0.64 | HRH3 (0.79) | ALDH1A1TSHRSMN1; SMN2NPSR1CYP2D6 | |
| SCHEMBL2502393 | 0.64 | ALDH1A1 (0.54) | ALDH1A1TSHRSMN1; SMN2NPSR1SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8080573-B2 | Heterocycle substituted amide and sulfur amide derivatives as histone deacetylase (hdac) inhibitors | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA (IT) | 2011-12-20 | — | — | US | disclosed |
| US-20090156619-A1 | Heterocycle Substituted Amide and Sulfur Amide Derivatives as Histone Deacetylase (HDAC) Inhibitors | MSD ITALIA S.R.L. (IT) | 2009-06-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090156619-A1 | Heterocycle Substituted Amide and Sulfur Amide Derivatives as Histone Deacetylase (HDAC) Inhibitors | HDAC1, HDAC6, HDAC11 | ALDH1A1 500/4885TSHR 758/4885SMN1; SMN2 404/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.