Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.52 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | PREP | P48147 | 2/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.45 |
| ▸ | ABL1 | P00519 | 1/20 | 0.44 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17229380 | 0.92 | HPGD (0.57) | HPGDEPHX1USP2SMN1; SMN2MEN1 | |
| SCHEMBL16925474 | 0.91 | HPGD (0.52) | HPGDEPHX1MEN1ALDH1A1MAPT | |
| SCHEMBL12082 | 0.88 | HPGD (0.55) | HPGDEPHX1USP2SMN1; SMN2MAPT | |
| Ammonia Solution, Strong SCHEMBL7871661 | 0.87 | HPGD (0.54) | HPGDEPHX1USP2SMN1; SMN2MAPT | |
| SCHEMBL13059809 | 0.86 | MEN1 (0.56) | HPGDEPHX1USP2SMN1; SMN2MEN1 | |
| SCHEMBL13059808 | 0.86 | MEN1 (0.56) | HPGDEPHX1USP2SMN1; SMN2MEN1 | |
| SCHEMBL9974300 | 0.86 | MEN1 (0.56) | HPGDEPHX1USP2SMN1; SMN2MEN1 | |
| SCHEMBL22765858 | 0.83 | HPGD (0.66) | HPGDEPHX1USP2SMN1; SMN2MEN1 | |
| SCHEMBL19852378 | 0.83 | HPGD (0.51) | HPGDEPHX1MEN1ALDH1A1MAPT | |
| SCHEMBL21142602 | 0.83 | HPGD (0.55) | HPGDEPHX1MEN1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8394955-B2 | 2,4 (4,6) pyrimidine derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 2013-03-12 | — | — | US | disclosed |
| US-20120065395-A1 | 2,4 (4,6) PYRIMIDINE DERIVATIVES | FREYNE EDDY JEAN EDGARD (BE) | 2012-03-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120065395-A1 | 2,4 (4,6) PYRIMIDINE DERIVATIVES | NR0B1, NR1H3, NCOA3 | HPGD 580/4885EPHX1 246/4885USP2 4690/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.