Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 6/20 | 0.75 |
| ▸ | NR2E3 | Q9Y5X4 | 2/20 | 0.56 |
| ▸ | MMP2 | P08253 | 1/20 | 0.53 |
| ▸ | MMP9 | P14780 | 1/20 | 0.53 |
| ▸ | COMT | P21964 | 1/20 | 0.53 |
| ▸ | MMP8 | P22894 | 1/20 | 0.53 |
| ▸ | MMP13 | P45452 | 1/20 | 0.53 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.53 |
| ▸ | PRSS12 | P56730 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | THRB | P10828 | 1/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
| ▸ | KDR | P35968 | 3/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1250343 | 0.95 | DGAT1 (0.80) | DGAT1NR2E3MMP2MMP9COMT | |
| SCHEMBL1250241 | 0.92 | DGAT1 (0.75) | DGAT1NR2E3MMP2MMP9COMT | |
| SCHEMBL1249930 | 0.91 | DGAT1 (0.85) | DGAT1NR2E3MMP2MMP9COMT | |
| SCHEMBL1249424 | 0.89 | DGAT1 (0.82) | DGAT1NR2E3CHEK2KDM4EMEN1 | |
| SCHEMBL1251151 | 0.89 | DGAT1 (0.71) | DGAT1NR2E3COMTMEN1NPC1 | |
| SCHEMBL1248424 | 0.88 | DGAT1 (0.67) | DGAT1MMP2MMP9MMP8MMP13 | |
| SCHEMBL1250402 | 0.87 | DGAT1 (0.75) | DGAT1NR2E3MMP2MMP9MMP8 | |
| SCHEMBL1249997 | 0.87 | DGAT1 (0.82) | DGAT1NR2E3CHEK2KDM4EMEN1 | |
| SCHEMBL1250221 | 0.87 | DGAT1 (0.85) | DGAT1NR2E3CHEK2KDRITGB1 | |
| SCHEMBL11411628 | 0.86 | DGAT1 (0.68) | DGAT1NR2E3CHEK2KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2074089-A2 | ORGANIC COMPOUNDS | Novartis AG (CH) | 2009-07-01 | — | — | EP | disclosed |
| WO-2008048991-A2 | ORGANIC COMPOUNDS | NOVARTIS AG (CH) | 2008-04-24 | — | — | WO | disclosed |