Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.41 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.41 |
| ▸ | CDK8 | P49336 | 3/20 | 0.38 |
| ▸ | PDCD1 | Q15116 | 3/20 | 0.36 |
| ▸ | CD274 | Q9NZQ7 | 3/20 | 0.36 |
| ▸ | PRMT6 | Q96LA8 | 7/20 | 0.35 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.35 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.34 |
| ▸ | HPGDS | O60760 | 2/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
| ▸ | CFD | P00746 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4162033 | 0.92 | TGFBR1 (0.42) | CYP3A4CYP2C8TGFBR1PDCD1CD274 | |
| SCHEMBL4163539 | 0.92 | TGFBR1 (0.44) | CYP3A4CYP2C8TGFBR1CDK8PDCD1 | |
| SCHEMBL4159244 | 0.89 | TGFBR1 (0.45) | CYP3A4CYP2C8TGFBR1CDK8PRKCQ | |
| SCHEMBL4150529 | 0.88 | CYP3A4 (0.40) | CYP3A4CYP2C8TGFBR1CDK8CD274 | |
| SCHEMBL4155004 | 0.87 | CDK8 (0.49) | CYP3A4CYP2C8TGFBR1CDK8CFD | |
| SCHEMBL4156341 | 0.87 | CYP3A4 (0.39) | CYP3A4CYP2C8TGFBR1CDK8CD274 | |
| SCHEMBL3722712 | 0.86 | TGFBR1 (0.39) | CYP3A4CYP2C8TGFBR1CDK8PDCD1 | |
| SCHEMBL4155519 | 0.86 | TGFBR1 (0.45) | CYP3A4CYP2C8TGFBR1PDCD1CD274 | |
| SCHEMBL27808283 | 0.86 | TGFBR1 (0.39) | CYP3A4CYP2C8TGFBR1CDK8PRMT6 | |
| SCHEMBL3664849 | 0.84 | CYP3A4 (0.43) | CYP3A4CYP2C8TGFBR1CDK8PDCD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101970435-B | Pyrrolopyrimidines and pyrrolopyridines | NOVARTIS AG | 2014-07-02 | — | — | CN | claimed |
| CN-101970435-A | Pyrrolopyrimidines and pyrrolopyridines | NOVARTIS AG | 2011-02-09 | — | — | CN | claimed |
| CN-101970435-B | Pyrrolopyrimidines and pyrrolopyridines | NOVARTIS AG | 2014-07-02 | — | — | CN | disclosed |
| US-8314112-B2 | Pyrrolopyrimidines and pyrrolopyridines | NOVARTIS AG (CH) | 2012-11-20 | — | — | US | disclosed |
| CN-101970435-A | Pyrrolopyrimidines and pyrrolopyridines | NOVARTIS AG | 2011-02-09 | — | — | CN | disclosed |
| US-20090181941-A1 | Pyrrolopyrimidines and Pyrrolopyridines | NOVARTIS AG (CH) | 2009-07-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090181941-A1 | Pyrrolopyrimidines and Pyrrolopyridines | ALK, ACVR1, PTPN4 | CYP3A4 111/4885CYP2C8 1297/4885TGFBR1 128/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.